🧬 Longevity Peptides

Age Slower.
Live Longer.
The Science Is Here.

Research-grade peptides that target the cellular mechanisms of ageing — telomere extension, senolytic activity, and mitochondrial renewal. Shipped discreetly across Canada.

Shop Longevity → The Science

+33%

Telomere Lengthening

99%+

Purity Verified

4–8wk

Noticeable Effects

🔬

Telomere Support

Epithalon, FOXO4-DRI, ARA-290

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Mitochondrial Health

NAD+, MOTS-C, Glutathione

🧠

Cognitive Longevity

Semax, DSIP, Cerebrolysin

🍁

Ships Across Canada

Discreet packaging, tracked delivery

How Longevity Peptides Work

Longevity peptides target the root causes of biological ageing — telomere shortening, senescent cell accumulation, mitochondrial dysfunction, and declining NAD+ levels.

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Telomere Extension

Epithalon activates telomerase, the enzyme that extends telomere length — directly addressing one of the primary hallmarks of cellular ageing.

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Senolytic Activity

FOXO4-DRI selectively eliminates senescent "zombie" cells that accumulate with age and drive chronic inflammation.

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Mitochondrial Renewal

NAD+ and MOTS-C restore mitochondrial function — the energy currency of every cell in your body declines sharply after 40.

🛡️

Cellular Protection

GHK-Cu and Glutathione activate the body's own antioxidant and repair pathways, reducing oxidative damage at the cellular level.

The Science

Targeting the Hallmarks of Ageing at the Molecular Level

Modern longevity science has identified nine hallmarks of ageing — from genomic instability to stem cell exhaustion. Longevity peptides are among the most targeted tools available to address these mechanisms directly.

Telomerase Activation (Epithalon)

Epithalon (Epitalon) is a tetrapeptide derived from the pineal gland that stimulates telomerase activity, extending telomere length in human cell cultures and animal models.

FOXO4-p53 Disruption

FOXO4-DRI is a D-amino acid retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells, triggering apoptosis while leaving healthy cells unaffected.

NAD+ Precursor Pathway

NAD+ levels decline ~50% between ages 40 and 60. Supplementing NAD+ directly restores sirtuin activity, DNA repair capacity, and mitochondrial biogenesis.

Longevity Peptides

View All →

SubQ

Pinealon

Pinealon — tripeptide bioregulator of central nervous system aging that restores neuronal…

cjc-1295

Sermorelin / CJC-1295 Longevity Stack

12–16 week longevity protocol. GH secretagogue stack for anti-aging.

SubQ

AICAR

AICAR — AMPK activator and exercise-mimetic compound that drives fat oxidation, mitochondrial…

SubQ

HGH (Human Growth Hormone)

HGH — endogenous somatotropin that drives IGF-1 production, promotes lipolysis, stimulates muscle…

SubQ

5-Amino-1MQ

5-Amino-1MQ — NNMT inhibitor that preserves NAD⁺, activates SIRT1, and supports fat…

SubQ

Glutathione

Glutathione — the body's master antioxidant and liver's primary detoxification molecule, with…

SubQ

CJC-1295 / Ipamorelin Blend

CJC-1295 / Ipamorelin — pre-combined GHRH and ghrelin-axis co-agonism for synergistic GH…

SubQ

FOXO4-DRI

FOXO4-DRI — first-in-class senolytic peptide that selectively eliminates senescent cells by disrupting…

Which Longevity Peptide Is Right for You?

Each peptide targets a different hallmark of ageing. Use this guide to find your best starting point.

Peptide	Primary Target	Key Mechanism	Cycle	Best For
Epithalon	Telomere Length	Telomerase activation	10–20 days/yr	Anti-ageing foundation	View →
FOXO4-DRI	Senescent Cells	Senolytic apoptosis	3×/week, 3 weeks	Inflammation + frailty
NAD+	Mitochondria	Sirtuin activation	Daily	Energy + DNA repair	View →
MOTS-C	Metabolic Health	AMPK + mitochondria	3–5×/week	Metabolic longevity	View →
GHK-Cu	Tissue Repair	Copper peptide signalling	Daily	Skin + wound healing	View →
Glutathione	Oxidative Stress	Master antioxidant	Daily	Detox + cellular protection

Research Protocols

Evidence-based dosing protocols used in longevity research. Always consult a healthcare professional before beginning any peptide protocol.

Dose

5–10 mg

Administered as a SubQ injection once daily, typically in the morning

Frequency

Daily × 10–20 days

Short intensive course, 1–2 times per year. Research suggests benefits persist for months after the cycle ends

Cycle

1–2× per year

Annual or biannual cycles are the most common research protocol. No receptor desensitisation observed

Dose

1–2 mg/kg

FOXO4-DRI is a potent senolytic — start at the lower end and assess tolerance

Frequency

3× per week

Administered on alternating days for 3 weeks. Some research protocols use a single intensive week

Cycle

1× per year

Annual senolytic clearance protocol. Significant reductions in senescent cell burden documented in research

Dose

250–500 mg

NAD+ administered as a SubQ or IV injection. SubQ is more practical for home use

Frequency

Daily

Continuous daily supplementation maintains elevated NAD+ levels. Benefits compound over time

Duration

Ongoing

NAD+ is a naturally occurring coenzyme — ongoing supplementation is appropriate given natural age-related decline

What the Research Shows

Longevity peptides have some of the most compelling research in the peptide space — with decades of study behind the leading compounds.

+33%

Telomere lengthening with Epithalon in human cell studies

−50%

Senescent cell burden reduction with FOXO4-DRI in mouse models

+40%

Mitochondrial function improvement with NAD+ supplementation

25yr

Of Epithalon research — one of the most studied longevity peptides

Peer-Reviewed Research

Every longevity peptide we carry has a published research foundation.

Rejuvenation Research · 2003

Epithalon Increases Telomere Length in Human Somatic Cells

Epithalon (Epitalon) was shown to increase telomere length and telomerase activity in human somatic cells, suggesting a direct anti-ageing mechanism at the chromosomal level.

Read Study →

Cell · 2017

FOXO4-DRI Clears Senescent Cells and Restores Physical Fitness

FOXO4-DRI selectively induced apoptosis in senescent cells in vivo, leading to improved physical fitness, fur density, and renal function in aged mice.

Read Study →

Cell Metabolism · 2013

NAD+ Repletion Improves Mitochondrial and Stem Cell Function

Restoring NAD+ levels in aged mice reversed mitochondrial dysfunction and improved muscle stem cell function, pointing to NAD+ as a key longevity target.

Read Study →

What Our Customers Say

★★★★★

"Running my second annual Epithalon cycle. Sleep quality improved dramatically in the first week — deeper sleep, more vivid dreams. Energy levels are noticeably better. The COA matched exactly what I expected from a premium supplier."

Robert K. Verified

Toronto, ON · Longevity Protocol

★★★★★

"Added NAD+ to my daily protocol 3 months ago. The cognitive clarity and sustained energy throughout the day are genuinely remarkable. Poptides is the only Canadian supplier I trust for this."

Linda M. Verified

Victoria, BC · Biohacking

★★★★★

"FOXO4-DRI is not easy to find in Canada. Poptides had it in stock, the packaging was discreet, and the product quality was excellent. Noticed reduced joint inflammation within 2 weeks of the protocol."

James W. Verified

Ottawa, ON · Anti-Ageing

Frequently Asked Questions

Results vary by compound. Epithalon users typically report improved sleep quality within the first week of a cycle. NAD+ effects on energy and cognition are often noticed within 2–4 weeks. Senolytic effects from FOXO4-DRI may take longer to manifest as measurable changes in inflammation markers.

Yes — many longevity researchers stack Epithalon with NAD+ for a synergistic effect on telomere health and mitochondrial function. GHK-Cu pairs well with both. FOXO4-DRI is typically run as a standalone protocol due to its potency. We recommend starting with one compound and adding others once you understand your individual response.

Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from Epithalamin, a natural polypeptide extracted from the pineal gland. It was developed by Russian gerontologist Vladimir Khavinson and has over 25 years of published research behind it, including human clinical trials showing telomere lengthening, improved melatonin production, and extended lifespan in animal models.

Injectable NAD+ has significantly higher bioavailability than oral forms. Oral precursors (NMN, NR) are converted to NAD+ in the body but at lower efficiency. For research purposes, SubQ injection of NAD+ produces the most reliable and measurable increases in cellular NAD+ levels.

Poptides sells peptides for research purposes only. They are not approved for human use by Health Canada and are not intended to diagnose, treat, cure, or prevent any disease. Please consult a healthcare professional before use.

Age Slower.Live Longer.The Science Is Here.

Pinealon

Sermorelin / CJC-1295 Longevity Stack

AICAR

HGH (Human Growth Hormone)

5-Amino-1MQ

Glutathione

CJC-1295 / Ipamorelin Blend

FOXO4-DRI

Start Your Longevity Protocol Today

Age Slower.
Live Longer.
The Science Is Here.