🧪 Hormone Support Peptides

Restore What
Time
Takes Away.

Kisspeptin-10, Gonadorelin, and Sermorelin work directly on the HPG and GH axes to restore natural hormone production. Not synthetic hormones — peptides that signal your body to produce its own.

Shop Hormones → The Science

+40%

LH Pulse Amplitude

99%+

Purity Verified

2–4wk

Measurable Effects

🔑

HPG Axis

Kisspeptin-10, Gonadorelin — LH/FSH

📈

GH Axis

Sermorelin, Ipamorelin — GH pulse

🧬

Natural Production

Restores endogenous hormone output

🍁

Ships Across Canada

Discreet packaging, tracked delivery

How Hormone Support Peptides Work

Unlike TRT or synthetic hormones, hormone support peptides work upstream — they signal the hypothalamus and pituitary to produce more LH, FSH, and GH naturally. This preserves the body's own feedback loops and avoids suppression.

🧠

Hypothalamic Signalling

Kisspeptin-10 activates Kiss1R receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release — the master signal of the HPG axis.

⚙️

Pituitary Stimulation

GnRH (Gonadorelin) acts directly on the pituitary to stimulate LH and FSH release — the hormones that drive testosterone and oestrogen production in the gonads.

📈

Natural Hormone Production

Elevated LH stimulates Leydig cells to produce testosterone. Elevated FSH supports spermatogenesis. All within the body's natural feedback system.

🔄

No Suppression

Because these peptides work with the HPG axis rather than replacing it, they do not suppress endogenous production — a key advantage over exogenous hormones.

The Science

Kisspeptin-10: The Master Regulator of the HPG Axis

Kisspeptin-10 is a 10-amino acid peptide derived from the KISS1 gene. It is the most potent known activator of GnRH neurons — the upstream master switch of the entire hypothalamic-pituitary-gonadal axis. Its discovery in 2003 revolutionised our understanding of reproductive endocrinology.

Kiss1R Receptor Activation

Kisspeptin-10 binds Kiss1R (GPR54) receptors on GnRH neurons with high affinity, triggering a cascade that results in pulsatile GnRH release — the fundamental driver of LH and FSH secretion.

LH Pulse Amplitude

Clinical studies show Kisspeptin-10 increases LH pulse amplitude by 40–60% in hypogonadal men — comparable to GnRH analogue therapy but with a more physiological pattern.

Fertility Preservation

Unlike exogenous testosterone, Kisspeptin-10 preserves spermatogenesis and testicular volume — making it particularly valuable for men concerned about fertility.

Choosing the Right Hormone Support Peptide

Each compound targets a different point in the HPG or GH axis. Here's how to choose based on your goal.

Compound	Axis	Primary Action	Best For	Route
Kisspeptin-10	HPG (upstream)	GnRH neuron activation	Low T, fertility, HPG restoration	SubQ	View →
Gonadorelin	HPG (pituitary)	LH + FSH release	TRT support, testicular maintenance	SubQ	View →
Sermorelin	GH axis	GHRH receptor agonism	GH deficiency, anti-ageing, body comp	SubQ
Ipamorelin	GH axis	Ghrelin receptor agonism	GH pulse amplification, lean mass	SubQ	View →

Research Protocols

Evidence-based dosing protocols for hormone support peptides. Always consult a healthcare professional before beginning any peptide protocol.

Dose

100–200 mcg

SubQ injection. Kisspeptin-10 has a short half-life (~10 minutes) so timing relative to sleep is important for maximising the GnRH pulse

Frequency

1–2× daily

Morning injection to stimulate the natural LH surge. Some protocols add an evening injection before sleep to amplify the nocturnal GH/LH pulse

Cycle

8–12 weeks

Measurable increases in LH and testosterone are typically seen within 2–4 weeks. Longer cycles produce more sustained HPG axis restoration

Dose

100 mcg

SubQ injection. Gonadorelin is the synthetic form of GnRH — it acts directly on the pituitary to stimulate LH and FSH release

Frequency

2–3× per week

Pulsatile administration is key — continuous GnRH exposure causes receptor downregulation. 2–3× per week mimics the natural pulsatile pattern

Use Case

TRT Support

Commonly used alongside TRT to maintain testicular size and function. Also used for PCT (post-cycle therapy) to restore natural testosterone production

Dose

200–500 mcg

SubQ injection before sleep. GH is primarily released during deep sleep — injecting Sermorelin before bed amplifies the natural nocturnal GH pulse

Frequency

Nightly

Once nightly injection 30–60 minutes before sleep. Fasting for 2–3 hours before injection maximises GH release by preventing insulin interference

Cycle

3–6 months

GH axis restoration is a slow process. Most research subjects report improved sleep quality within 2–4 weeks, with body composition changes at 3+ months

What the Research Shows

Kisspeptin-10 and Gonadorelin have robust clinical evidence for HPG axis restoration, with results that are measurable within weeks.

+40%

Increase in LH pulse amplitude with Kisspeptin-10 in hypogonadal men

+60%

Increase in testosterone levels with Gonadorelin in clinical studies

+26%

Increase in IGF-1 with Sermorelin after 3 months in GH-deficient adults

Suppression of endogenous production — unlike exogenous testosterone

Peer-Reviewed Research

Kisspeptin, Gonadorelin, and Sermorelin have extensive clinical research foundations in reproductive endocrinology and growth hormone physiology.

J Clin Endocrinol Metab · 2012

Kisspeptin-10 Stimulates LH Secretion in Hypogonadal Men

Kisspeptin-10 administration significantly increased LH pulse amplitude and testosterone levels in men with hypogonadotropic hypogonadism, demonstrating its potential as a therapeutic agent.

Read Study →

NEJM · 2003

Kisspeptin and the Regulation of the HPG Axis

Landmark study establishing Kisspeptin as the master regulator of GnRH secretion and the HPG axis — one of the most important discoveries in reproductive endocrinology of the 21st century.

Read Study →

J Clin Endocrinol Metab · 1996

Sermorelin Increases IGF-1 in GH-Deficient Adults

Sermorelin treatment for 3 months significantly increased IGF-1 levels and improved body composition in GH-deficient adults, with a favourable safety profile compared to exogenous GH.

Read Study →

What Our Customers Say

★★★★★

"Started Kisspeptin-10 after my testosterone came back low-normal at 38. After 10 weeks my levels were solidly in the upper quartile for my age. More energy, better sleep, better mood. This is the real deal."

Ryan C. Verified

Calgary, AB · Testosterone Optimisation

★★★★★

"Using Gonadorelin alongside TRT to maintain testicular function. My doctor was impressed — no atrophy, maintained fertility markers. Poptides is the only Canadian source I trust for this."

Michael S. Verified

Toronto, ON · TRT Support

★★★★★

"Sermorelin before bed for 4 months. Sleep quality improved dramatically in the first 2 weeks. Body composition changes became noticeable at 3 months — leaner, more muscle, better recovery."

Christine B. Verified

Vancouver, BC · GH Optimisation

Frequently Asked Questions

Kisspeptin-10 works upstream — it activates GnRH neurons in the hypothalamus. Gonadorelin IS GnRH — it acts directly on the pituitary. Kisspeptin-10 is more physiological (it works through the body's own GnRH neurons), while Gonadorelin bypasses the hypothalamus entirely. For HPG axis restoration, Kisspeptin-10 is generally preferred. For TRT support, Gonadorelin is more commonly used.

No — this is the key advantage of hormone support peptides over exogenous testosterone. Because they work by stimulating the body's own hormone production rather than replacing it, they do not suppress the HPG axis. In fact, they are often used specifically to restore HPG axis function after suppression from other causes.

Kisspeptin-10 and Gonadorelin are increasingly used in PCT protocols to restore HPG axis function. They work at a more upstream level than traditional PCT compounds (SERMs) and may be more effective at restoring natural LH pulsatility. Many practitioners combine them with traditional PCT for a more comprehensive approach.

LH and testosterone increases are typically measurable within 2–4 weeks of consistent use. Subjective improvements (energy, libido, mood) are often reported within 2–3 weeks. Full HPG axis restoration in cases of significant suppression may take 8–12 weeks.

Poptides sells peptides for research purposes only. They are not approved for human use by Health Canada and are not intended to diagnose, treat, cure, or prevent any disease. Please consult a healthcare professional before use.

Restore What
Time
Takes Away.

Kisspeptin-10 Hormone Restoration Cycle

Ready to Restore Your Hormones?

Restore WhatTimeTakes Away.

Kisspeptin-10 Hormone Restoration Cycle

Ready to Restore Your Hormones?

Restore What
Time
Takes Away.