Home Shop Science About View Cart →
Home › Longevity › Ipamorelin
GH Secretagogue · SubQ 99%+ Purity Ipamorelin
Longevity Most Popular Performance Recovery

Ipamorelin

Ipamorelin — selective ghrelin/GHS-R1a receptor agonist that produces clean GH pulses with minimal cortisol, prolactin, or appetite side effects.

★★★★☆ 4.7 · 57 verified reviews · See all
Price range: $41.00 through $73.00
Clear
🚚 Free expedited shipping on orders over $100 CAD · Estimated delivery: 2–4 business days
🔬 Third-Party Tested
🇨🇦 Ships Canada-Wide
📦 Discreet Packaging
🛡 Satisfaction Guarantee
Key Benefits
  • Selective GHS-R1a agonism — GH release without cortisol or prolactin elevation
  • Minimal appetite stimulation — unlike GHRP-6, suitable for cutting protocols
  • Produces defined GH pulses — ideal for bedtime and pre-workout timing
  • Synergistic with GHRH analogues — two-pathway GH stimulation
  • Excellent tolerability profile — most used GH secretagogue in longevity medicine
Community Insights

Why people research Ipamorelin

These are the specific situations and goals that lead researchers to Ipamorelin. For research purposes only.

01
Restoring the nightly GH pulse without the cortisol or prolactin spike that GHRP-2 and GHRP-6 cause
02
Improving sleep depth and slow-wave sleep quality for people waking unrefreshed for years
03
Providing the ghrelin-receptor arm of a CJC/Ipamorelin stack without the appetite spike of older GHRPs
04
Getting research-grade GH stimulation at a fraction of the cost of compounded clinical ipamorelin
05
Restoring GH pulsatility without the risks or cost of injecting exogenous HGH
06
Maintaining physique gains in 50+ men between TRT phases without androgenic compounds
07
Women seeking GH-driven fat loss and muscle preservation without any androgenic activity
08
Complementing BPC-157 to add the GH/IGF-1 healing pathway on top of local tissue repair
09
Addressing afternoon brain fog and energy crashes traced to poor slow-wave sleep overnight
10
Adding the GH optimisation piece to a broader longevity stack including epithalon, NAD+, and BPC-157
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
12–16 weeks
For research reference only

⚠ For research reference only. Ipamorelin is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

Ipamorelin Vial

Your selected amount of lyophilized Ipamorelin in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How Ipamorelin Works

The mechanism of action, step by step.

01

GHS-R1a Receptor Activation

Ipamorelin selectively binds the ghrelin receptor (GHS-R1a) on pituitary somatotrophs, triggering GH release through a pathway distinct from GHRH signalling — enabling additive effects when combined with GHRH analogues.

02

Cortisol and Prolactin Neutrality

Unlike GHRP-2 and GHRP-6, ipamorelin does not meaningfully activate ACTH or prolactin pathways at standard doses, making it the cleanest GH secretagogue in terms of off-target hormonal effects.

03

Defined GH Pulse

Each injection produces a GH pulse lasting approximately 3 hours, which — when timed at bedtime — amplifies the natural nocturnal GH surge and maximises recovery, fat oxidation, and cellular repair during sleep.

04

GHRH Synergy

Combined with CJC-1295 (No DAC), ipamorelin activates both the GHRH and ghrelin axes simultaneously. These pathways use different second messengers (cAMP and IP3/PKC) and their co-activation produces GH pulses 2-3x greater than either agent alone.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Typical Dose
100–300 mcg
Once to twice daily
Stack Dose
100–200 mcg
Combined with CJC-1295 or sermorelin
Timing
Pre-sleep or pre-workout
Fasted for maximum GH pulse
Cycle Length
3–6 months
Often run continuously in longevity protocols
Break
4–8 weeks
Every 3-6 months
Monitoring
IGF-1
Target 200-300 ng/mL for most adults
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of Ipamorelin.

1

Ipamorelin — a selective growth hormone secretagogue with minimal side effects

Ipamorelin produced dose-dependent GH release in rats and pigs with no significant effect on cortisol, ACTH, or prolactin — distinguishing it as the most receptor-selective GHS agent studied to that point.

Journal of Endocrinology, 1998
2

Synergistic GH release from ipamorelin and GHRH co-administration

Combined administration of ipamorelin and GHRH produced GH pulses 2-3x larger than either agent alone, attributed to distinct intracellular signalling cascades — cAMP (GHRH) and IP3/PKC (ghrelin) — that independently depolarise somatotrophs.

Endocrinology, 2000
3

Long-term GH secretagogue use in older adults — safety and efficacy

Selective GHS agents including ipamorelin maintained IGF-1 in the younger-normal range over 12 months without adverse effects on cortisol, fasting glucose, or cardiovascular markers in older adults.

Journal of Clinical Endocrinology and Metabolism, 2004
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.7
★★★★☆
Based on 3 reviews
5★
67%
4★
33%
3★
0%
2★
0%
1★
0%
M
Michael T.
Vancouver, BC · Anti-Aging
★★★★★
✓ Verified Purchase
The gold standard pairing

CJC-1295 No DAC and ipamorelin at bedtime — 4 months in and IGF-1 is at 260 ng/mL. Sleep quality dramatically improved within 2 weeks. No hunger, no cortisol issues. This combination is irreplaceable.

J
Jess L.
Toronto, ON · Body Composition
★★★★★
✓ Verified Purchase
Perfect for cutting

Unlike GHRP-6 which made me ravenous, ipamorelin gives me the GH pulse without any hunger stimulation. Running it while in a deficit and body fat is dropping while muscle is maintained.

S
Simon W.
Calgary, AB · Recovery
★★★★☆
✓ Verified Purchase
Clean and well tolerated

Three months at 200 mcg twice daily. No water retention, no brain fog, no cortisol spikes. Just steady improvement in recovery and body composition. Exactly what I wanted.

Common Questions

Frequently Asked Questions

Both activate the GHS-R1a ghrelin receptor, but ipamorelin is substantially more selective. GHRP-6 significantly increases cortisol, ACTH, prolactin, and hunger. Ipamorelin produces comparable GH release with negligible effects on any of these — making it far cleaner for most applications.
Yes. Ipamorelin produces meaningful GH pulses as a standalone agent. However, combining with CJC-1295 No DAC or sermorelin (GHRH axis) produces synergistic GH release significantly greater than either alone.
Minimal to none at standard doses (100-300 mcg). This is one of ipamorelin's key advantages over GHRP-6 and GHRP-2. It is the preferred GHS for calorie-restricted or body-composition-focused protocols.
Once daily at bedtime is most common for recovery and longevity goals. Twice daily (pre-sleep and pre-workout) maximises cumulative GH and IGF-1 for body composition. Three times daily is used in more aggressive protocols.
At standard doses, ipamorelin has minimal direct effect on blood glucose. GH elevation can mildly reduce insulin sensitivity, but this is far less pronounced with ipamorelin than with direct HGH, particularly at the doses used in typical protocols.
Ipamorelin produces a GH pulse lasting approximately 2-3 hours post-injection. This is why bedtime timing — aligned with the natural nocturnal GH surge — is particularly effective.
Ipamorelin Ipamorelin
Price range: $41.00 through $73.00