Home Shop Science About View Cart →
Home › Fat Loss › 5-Amino-1MQ
NNMT Inhibitor · Oral 99%+ Purity 5-Amino-1MQ
Fat Loss Longevity

5-Amino-1MQ

5-Amino-1MQ — NNMT inhibitor that preserves NAD⁺, activates SIRT1, and supports fat oxidation.

★★★★☆ 4.7 · 47 verified reviews · See all
Price range: $49.00 through $109.00
Clear
🚚 Free expedited shipping on orders over $100 CAD · Estimated delivery: 2–4 business days
🔬 Third-Party Tested
🇨🇦 Ships Canada-Wide
📦 Discreet Packaging
🛡 Satisfaction Guarantee
Key Benefits
  • Inhibits NNMT — preserves NAD+ for mitochondrial energy production
  • Activates SIRT1 — supports fat oxidation and muscle preservation
  • Promotes healthy weight management without stimulants
  • Supports metabolic flexibility and insulin sensitivity
  • Oral administration — no injection required
Community Insights

Why people research 5-Amino-1MQ

These are the specific situations and goals that lead researchers to 5-Amino-1MQ. For research purposes only.

01
Reversing the fat-storage effect of NNMT enzyme overactivation
targeting the root driver of visceral fat accumulation without calorie restriction
02
Breaking through a fat loss plateau on a GLP-1 by adding a complementary metabolic mechanism that operates independently of appetite suppression
03
Preserving lean muscle mass during an aggressive calorie deficit
the NNMT inhibition effect shifts fuel use toward fat without catabolising protein
04
Improving energy output from existing fat stores
restoring the burning feeling during training that faded during prolonged dieting
05
Adding oral metabolic support for needle-averse people who want the metabolic benefits of peptide protocols without injections
06
Stacking with semaglutide or tirzepatide to accelerate fat loss beyond what the GLP-1 alone delivers
a separate oral mechanism from a capsule
07
Targeting subcutaneous and visceral fat simultaneously when resistance training and diet have stalled body recomposition progress
08
Improving insulin sensitivity during a lean bulk to stay leaner while eating in a caloric surplus
09
Recovering from metabolic adaptation
the drop in TDEE that accompanies prolonged calorie restriction — by restoring NAD+ pathway efficiency
10
Using the NNMT inhibition pathway as part of a broader longevity stack alongside NAD+ and GH peptides
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
8–12 weeks
For research reference only

⚠ For research reference only. 5-Amino-1MQ is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

5-Amino-1MQ Vial

Your selected amount of lyophilized 5-Amino-1MQ in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How 5-Amino-1MQ Works

The mechanism of action, step by step.

01

NNMT Inhibition

Selectively binds and inhibits nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue that consumes NAD+ precursors.

02

NAD+ Preservation

By blocking NNMT activity, cellular NAD+ levels rise, fuelling the mitochondrial electron transport chain and supporting sustained energy output.

03

SIRT1 Activation

Elevated NAD+ activates SIRT1 (Sirtuin-1), a key metabolic regulator that promotes fat oxidation, reduces lipid accumulation, and supports lean body composition.

04

Metabolic Remodelling

Chronic NNMT inhibition shifts the metabolic set point, reducing fat storage signals and improving the body's capacity to mobilise and burn stored energy.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Cycle Length
8 Weeks
Followed by 2-week break
Reassess
Week 4
Adjust dose based on response
Long-term
Ongoing cycles
Monitor metabolic markers quarterly
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of 5-Amino-1MQ.

1

NNMT inhibition increases NAD+ levels and enhances fatty acid oxidation

Demonstrated that small-molecule NNMT inhibitors rescue NAD+ depletion in adipocytes, leading to improved mitochondrial respiration and reduced lipid accumulation in diet-induced obese mice.

Nature Communications, 2021
Read →
2

SIRT1 activation downstream of NAD+ restoration improves metabolic syndrome markers

Restoring NAD+ bioavailability via NNMT inhibition activated SIRT1-dependent pathways, improving insulin sensitivity and reducing visceral adiposity in preclinical models.

Cell Metabolism, 2020
Read →
3

5-Amino-1MQ reduces adiposity without affecting food intake

In obese mouse models, 5-Amino-1MQ treatment for 8 weeks significantly reduced fat mass and improved metabolic parameters without altering caloric intake or locomotor activity.

Journal of Medicinal Chemistry, 2022
Read →
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.7
★★★★☆
Based on 3 reviews
5★
67%
4★
33%
3★
0%
2★
0%
1★
0%
M
Marcus T.
Vancouver, BC · Weight Loss
★★★★★
✓ Verified Purchase
Noticeable shift in body composition

After 6 weeks I can see real changes in my midsection that diet alone was not delivering. Energy levels are solid throughout the day.

D
Diane R.
Toronto, ON · GLP-1 Stack
★★★★★
✓ Verified Purchase
Great stacked with my GLP-1

Adding 5-Amino-1MQ alongside semaglutide has noticeably improved my results. Less plateau effect and better energy during the cut.

J
Jordan K.
Calgary, AB · Body Recomposition
★★★★☆
✓ Verified Purchase
Subtle but consistent

Not a dramatic overnight change, but over 8 weeks the trend is clearly positive. Leaner, more energy, better gym performance.

Common Questions

Frequently Asked Questions

NNMT (nicotinamide N-methyltransferase) is an enzyme found in fat tissue that consumes NAD+ precursors. When NNMT is overactive, NAD+ levels drop, blunting mitochondrial function and fat burning. 5-Amino-1MQ blocks this enzyme, helping restore NAD+ to healthy levels.
Most users notice improved energy within 2-3 weeks. Meaningful changes in body composition typically appear from week 4-6 onward, with the full effect realised over an 8-week cycle.
No. 5-Amino-1MQ is taken orally as a capsule, making it one of the most convenient NNMT inhibitors available.
Yes. 5-Amino-1MQ is commonly stacked with GLP-1 agonists for complementary fat-loss mechanisms. The two compounds work via distinct pathways, making them synergistic rather than redundant.
5-Amino-1MQ is generally well tolerated in research settings. No significant adverse effects have been reported at standard doses. As with all research compounds, start at the lower end of the dose range.
A common protocol is 8 weeks on, 2 weeks off. This allows for a reassessment of metabolic markers and prevents potential tolerance. Some users run continuous low-dose protocols under medical supervision.
5-Amino-1MQ 5-Amino-1MQ
Price range: $49.00 through $109.00