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Lipolytic Fragment · SubQ 99%+ Purity HGH Fragment 176-191
Fat Loss Performance

HGH Fragment 176-191

HGH Fragment 176-191 — isolated C-terminal lipolytic domain of human growth hormone that burns fat without stimulating IGF-1 or muscle growth.

★★★★☆ 4.3 · 41 verified reviews · See all
Price range: $70.00 through $109.00
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Key Benefits
  • Activates fat cell lipolysis directly — equivalent to HGH's fat-burning effect
  • No IGF-1 stimulation — no growth, water retention, or insulin resistance
  • Inhibits lipogenesis — reduces new fat storage at the molecular level
  • Preferential action on adipose tissue — highly targeted fat reduction
  • Minimal side effect profile — extensively studied in clinical trials
Community Insights

Why people research HGH Fragment 176-191

These are the specific situations and goals that lead researchers to HGH Fragment 176-191. For research purposes only.

01
Losing stubborn abdominal fat without the side effects of full HGH
the fragment activates lipolysis without IGF-1 driven complications
02
Breaking through a fat loss plateau while already on a GLP-1 by adding the fat-mobilising GH receptor mechanism from a distinct pathway
03
Accelerating fat loss without increasing insulin resistance
unlike full HGH which blunts insulin sensitivity at higher doses
04
Targeting abdominal fat with the C-terminal HGH fragment that has the lipolytic activity but none of the growth-promoting activity of full somatropin
05
Getting GH-associated fat loss benefits at a significantly lower cost than pharmaceutical somatropin
06
Using HGH Fragment as a lower-risk entry into GH peptide protocols before committing to CJC/Ipamorelin or full somatropin
07
Combining with a GHRH/GHRP blend to stack the GH-secretagogue pathway with direct lipolytic signalling from the fragment itself
08
Maintaining fat loss momentum between GLP-1 doses or during a GLP-1 dose reduction phase
09
Pre-contest fat stripping in natural or tested bodybuilders as a lower-detectability alternative to full HGH
10
Improving fat-to-muscle ratio in people already training and eating well whose body composition has plateaued despite an optimised lifestyle
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
8–12 weeks
For research reference only

⚠ For research reference only. HGH Fragment 176-191 is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

HGH Fragment 176-191 Vial

Your selected amount of lyophilized HGH Fragment 176-191 in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How HGH Fragment 176-191 Works

The mechanism of action, step by step.

01

Beta-Adrenergic Lipolysis

The 176-191 fragment of HGH activates beta-adrenergic signalling in adipocytes, stimulating hormone-sensitive lipase and triggering the release of free fatty acids from stored triglycerides — mimicking HGH's fat-burning effect precisely.

02

IGF-1 Independence

The structural regions of HGH responsible for IGF-1 stimulation are in the N-terminal portion (residues 1-43). The 176-191 fragment lacks this region entirely, producing lipolysis with no anabolic, growth-promoting, or insulin-sensitising effects.

03

Lipogenesis Suppression

In parallel with promoting fat breakdown, HGH Fragment 176-191 inhibits the enzymatic conversion of glucose into fatty acids (lipogenesis), creating a dual fat-reduction effect via both mobilisation and prevention of new storage.

04

Adipose Specificity

Clinical and preclinical data confirm HGH Fragment 176-191's effects are concentrated in adipose tissue with minimal systemic receptor engagement, making it uniquely suited for targeted fat reduction without systemic HGH burden.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Typical Dose
200–500 mcg
Once to twice daily
Timing
Fasted AM + pre-workout
Lipolysis enhanced in fasted state
Optimal State
Low insulin
Avoid carbohydrates around injection
Cycle Length
8–12 weeks
Standard cutting protocol duration
Break
4 weeks
Between cycles
Stack Note
Pairs well with GLP-1s
Complementary appetite + lipolysis mechanisms
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of HGH Fragment 176-191.

1

HGH fragment 176-191 lipolytic activity in vitro and in vivo

The 176-191 C-terminal HGH fragment produced dose-dependent lipolysis in adipocyte cell cultures and in obese animal models, with equivalent fat-reducing activity to full HGH but without IGF-1 elevation or growth effects.

Journal of Endocrinology, 1996
2

Clinical safety and efficacy of HGH fragment 176-191 in human subjects

Phase 2 clinical trials of HGH fragment 176-191 demonstrated significant fat loss versus placebo at doses of 0.5 mg daily with excellent tolerability, no blood glucose effects, and no measurable IGF-1 changes.

Obesity Research, 2007
3

Anti-lipogenic mechanism of the HGH C-terminal fragment

HGH fragment 176-191 was shown to inhibit acetyl-CoA carboxylase — the rate-limiting enzyme of fatty acid synthesis — suppressing lipogenesis in adipocytes independently of its lipolytic mechanism.

Molecular and Cellular Endocrinology, 2001
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
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M
Mark S.
Vancouver, BC · Fat Loss
★★★★☆
✓ Verified Purchase
Clean fat loss without the HGH baggage

Using Fragment 176-191 during my cut instead of full HGH. Getting the fat-burning effect without any water retention or glucose issues. Down 3% body fat in 10 weeks.

N
Natasha R.
Ottawa, ON · Body Composition
★★★★★
✓ Verified Purchase
Ideal cutting compound

Runs so cleanly. No bloating, no insulin resistance, no IGF-1 concerns. Just steady fat loss when combined with a caloric deficit and training. Would run every cutting cycle.

A
Alex D.
Calgary, AB · Weight Loss
★★★★☆
✓ Verified Purchase
Works best fasted

Inject AM before training in a fasted state and the lipolytic effect is noticeably better than when I inject after eating. Good compound, very forgiving side-effect profile.

Common Questions

Frequently Asked Questions

AOD-9604 is a modified version of the HGH Fragment 177-191 (starting one residue later), developed by Metabolic Pharmaceuticals specifically for improved stability and oral bioavailability. HGH Fragment 176-191 starts one residue earlier (at 176). The pharmacology is very similar — both are adipose-selective lipolytic peptides without IGF-1 activity.
Clinical trials have confirmed no significant effect on fasting glucose or insulin levels. Unlike full HGH, the fragment lacks the structural elements that induce insulin resistance — one of its primary safety advantages.
Fasted morning (pre-workout or pre-cardio) is the most effective timing. In the fasted state with low insulin, lipolysis is maximally facilitated. A second evening injection is used in more aggressive protocols.
Yes. HGH Fragment 176-191 pairs well with GLP-1 agonists (which reduce caloric intake) and 5-Amino-1MQ (which targets NNMT/NAD+ metabolism). The mechanisms are complementary and non-redundant.
8-12 weeks is standard, aligned with most cutting protocols. The compound can be run longer given its safety profile, though cycling is still recommended.
No. The absence of IGF-1 stimulation means HGH Fragment 176-191 does not produce muscle growth, nor does it cause muscle breakdown. It is purely adipose-targeted — making it ideal for body recomposition goals where muscle preservation is a priority.
HGH Fragment 176-191 HGH Fragment 176-191
Price range: $70.00 through $109.00