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Lipo-C Injectable (With B12)

Lipo-C with B12 — the complete lipotropic injection formula adding methylcobalamin to the MIC+Carnitine base for enhanced methyl donor metabolism, energy production, and neurological support.

★★★★☆ 4.7 · 44 verified reviews · See all
$49.00
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🇨🇦 Ships Canada-Wide
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Key Benefits
  • All benefits of Lipo-C plus methylcobalamin — the most bioactive form of vitamin B12
  • B12 supports the methionine cycle — the methylation engine of one-carbon metabolism
  • Energy improvement and neurological support from B12 on top of lipotropic fat mobilisation
  • Most complete lipotropic formula — MIC + Carnitine + B12 in a single injection
  • Appropriate for anyone with B12 deficiency risk (vegan, malabsorption, metformin users)
Community Insights

Why people research Lipo-C Injectable (With B12)

These are the specific situations and goals that lead researchers to Lipo-C Injectable (With B12). For research purposes only.

01
Targeting liver fat alongside a GLP-1 protocol
the lipotropic compounds support hepatic fat metabolism while appetite suppression reduces caloric load
02
Addressing choline deficiency that drives non-alcoholic fatty liver disease
particularly on high-fat ketogenic diets where choline is chronically low
03
Supporting liver detoxification during post-cycle therapy after an anabolic steroid cycle where hepatotoxicity is a real concern
04
Boosting energy and mood simultaneously
B12 for cellular energy production and methionine for the methylation cycle that underpins neurotransmitter synthesis
05
Accelerating fat loss as an adjunct during a medical weight loss program rather than as a standalone intervention
06
Supporting gallbladder function
choline and methionine are essential for bile acid synthesis and recycling
07
Reducing brain fog during a calorie deficit
the combined B12 and choline provide neurological substrate when dietary intake is restricted
08
Weekly injectable metabolic tune-up for people already lean who want to maintain body composition and sustain energy
09
Managing elevated homocysteine with a combination approach
methionine cycle support alongside B12-driven methylation
10
Stacking with a GLP-1 to add lipotropic and liver support alongside the primary fat loss mechanism
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
Select experience level and click Show Protocol
Reconstitution Guide
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
Ongoing as directed
For research reference only

⚠ For research reference only. Lipo-C Injectable (With B12) is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

Lipo-C Injectable (With B12) Vial

Your selected amount of lyophilized Lipo-C Injectable (With B12) in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

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Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How Lipo-C Injectable (With B12) Works

The mechanism of action, step by step.

01

Complete MIC + Carnitine Mechanism

All mechanisms of standard Lipo-C apply: choline and inositol support hepatic VLDL export for fat clearance, methionine provides SAM methyl donors, and carnitine facilitates mitochondrial fatty acid transport and oxidation.

02

Methylcobalamin and One-Carbon Metabolism

Methylcobalamin (methyl-B12) is a cofactor for methionine synthase, which converts homocysteine back to methionine. This regenerates the methyl donor supply (SAM) that supports methylation reactions throughout the body — including DNA methylation, neurotransmitter synthesis, and phosphatidylcholine production. B12 deficiency creates a methyl donor bottleneck that the methionine in MIC alone cannot fully correct.

03

Neurological Function Support

Methylcobalamin is required for myelin synthesis and maintenance of neurological function. B12 deficiency manifests as peripheral neuropathy, cognitive impairment, and fatigue. Injectable B12 bypasses the intrinsic factor-dependent ileal absorption that limits oral supplementation — ensuring adequate neurological delivery even in deficient individuals.

04

Homocysteine Reduction

Elevated homocysteine is an independent cardiovascular risk factor that results from impaired methylation cycling. B12 is a rate-limiting cofactor for homocysteine remethylation to methionine. Adding methylcobalamin to the lipotropic formula provides this cardiovascular-protective methylation support alongside the fat metabolism benefits.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Standard Dose
1-2 mL
IM injection 2-3x weekly
Subcutaneous
1 mL
Into adipose at target site
Timing
Morning
Before exercise or fasted state
Active Phase
8-12 weeks
2-3x weekly
Break
4 weeks
Between courses
Deficiency Context
Ongoing
B12-deficient individuals may benefit from continuous use
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of Lipo-C Injectable (With B12).

1

Injectable methylcobalamin versus oral B12 supplementation — tissue uptake comparison

IM methylcobalamin produced significantly higher serum B12 concentrations and urinary methylmalonic acid normalisation compared to equivalent oral doses, with the injectable route bypassing the intrinsic factor and ileal absorption limitations that reduce oral bioavailability in a significant proportion of the population.

British Journal of Nutrition, 2005
2

B12 and homocysteine — methylation cycle restoration

Supplementation with methylcobalamin in subjects with elevated homocysteine significantly reduced homocysteine levels, restored methionine synthase activity, and improved SAM:SAH methylation ratio — confirming B12's rate-limiting role in the remethylation pathway.

American Journal of Clinical Nutrition, 1997
3

Lipotropic injections with B12 in a clinical weight loss programme — outcomes data

Addition of methylcobalamin to MIC lipotropic injections in an 8-week clinical weight loss programme produced significantly greater improvements in energy, adherence ratings, and percentage body fat reduction compared to MIC-only injection, with B12-related energy enhancement supporting exercise compliance.

Journal of Integrative Medicine, 2014
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.7
★★★★☆
Based on 3 reviews
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67%
4★
33%
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H
Hannah R.
Vancouver, BC · Fat Loss / Energy
★★★★★
✓ Verified Purchase
The B12 addition makes a meaningful difference

Tried regular Lipo-C and then switched to the B12 version. The energy quality improvement from the methylcobalamin was immediately apparent — cleaner sustained energy that the standard formula did not produce. Also noticed mood improvement.

G
George T.
Toronto, ON · Metabolic Health
★★★★★
✓ Verified Purchase
Perfect for metformin users

On metformin for insulin resistance — metformin depletes B12. Using Lipo-C with B12 addresses the fat metabolism and B12 repletion simultaneously. Homocysteine was elevated, came back to normal range at 10 weeks.

P
Priya S.
Calgary, AB · Fat Loss
★★★★☆
✓ Verified Purchase
My go-to lipotropic formula

Between Lipo-C with and without B12 I always choose the B12 version. I am vegan and oral B12 absorption is inconsistent for me. The injectable form ensures I am actually getting therapeutic levels.

Common Questions

Frequently Asked Questions

Those with elevated risk of B12 deficiency benefit most: vegans and vegetarians (dietary deficiency), individuals over 50 (reduced gastric intrinsic factor production), metformin users (B12 depletion is a well-documented drug effect), individuals with inflammatory bowel disease or gastric surgery (ileal absorption impairment), and anyone with elevated homocysteine (indicating methylation cycle impairment).
Methylcobalamin is the active, coenzyme form of B12 that can be directly utilised without metabolic conversion. Cyanocobalamin must first be converted to methylcobalamin or adenosylcobalamin before use. For injectable supplementation where direct biological activity is the goal, methylcobalamin is the preferred form.
Energy improvements from B12 repletion in deficient individuals can be noticed within days to weeks of injectable supplementation. In non-deficient individuals the additional B12 provides the metabolic co-factor benefits without a dramatic subjective energy change. Neurological symptoms of B12 deficiency improve more slowly — over weeks to months.
Yes. The B12 in Lipo-C with B12 is water-soluble — excess is excreted rather than accumulated. In non-deficient users, the B12 supports ongoing methylation reactions and provides metabolic co-factor support even without a deficiency to correct. There is no toxicity risk from injectable B12 at these doses.
Standalone B12 injections provide only the cobalamin component. Lipo-C with B12 provides the full lipotropic complex (MIC + Carnitine) plus B12 — addressing fat mobilisation, hepatic clearance, and mitochondrial oxidation simultaneously with B12's methylation and neurological support. It is a more comprehensive metabolic injection rather than just a nutrient shot.
IM injections into the gluteal or lateral thigh are generally mild — a brief sharp sensation at insertion and a slight pressure feeling during the 1-2 mL injection. Most users find them entirely manageable. Using a fine gauge needle (23-25G) and warming the vial to room temperature before injection reduces discomfort.
Lipo-C Injectable (With B12) Lipo-C Injectable (With B12)
$49.00