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GH Secretagogue · SubQ 99%+ Purity Hexarelin
Performance Recovery

Hexarelin

Hexarelin — potent GHS-R1a agonist with dual action: significant GH release plus direct cardioprotective signalling via the CD36 receptor.

★★★★☆ 4.3 · 27 verified reviews · See all
Price range: $85.00 through $153.00
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🇨🇦 Ships Canada-Wide
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Key Benefits
  • Potent GH release — strongest GH secretagogue in the ghrelin class
  • Cardioprotective via CD36 receptor — independent of GH or IGF-1
  • Reduces cortisol elevation and cellular apoptosis in cardiac tissue
  • Improves exercise capacity and cardiac output in research models
  • Useful where cardiovascular support alongside GH optimisation is a priority
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 2mg vial + 2mL BAC water
Suggested Cycle Length
6–8 weeks
For research reference only

⚠ For research reference only. Hexarelin is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

Hexarelin Vial

Your selected amount of lyophilized Hexarelin in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How Hexarelin Works

The mechanism of action, step by step.

01

GHS-R1a Potent Agonism

Hexarelin is among the most potent GHS-R1a agonists studied, producing strong GH release from pituitary somatotrophs. Its greater receptor binding affinity compared to ipamorelin results in larger GH pulses but also more cortisol and prolactin elevation.

02

CD36 Cardiac Receptor Signalling

Hexarelin uniquely activates the CD36 receptor in cardiac muscle independently of GH or GHS-R1a, producing direct cardioprotective effects — reducing ischaemia-reperfusion injury, cardiomyocyte apoptosis, and oxidative stress.

03

Cortisol Moderation

Despite activating ACTH pathways more than ipamorelin, hexarelin's cardioprotective CD36 activity independently reduces cortisol-driven apoptosis in cardiac and skeletal muscle, partially offsetting its hormonal side-effect profile.

04

IGF-1 Elevation

The substantial GH pulses produced by hexarelin drive meaningful hepatic IGF-1 production, mediating downstream muscle protein synthesis, fat oxidation, and tissue repair.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Typical Dose
100–200 mcg
Once to twice daily
Cardiac Focus
50–100 mcg
Lower doses for cardioprotective use
Timing
Fasted, pre-sleep or AM
Maximum GH pulse in fasted state
Cycle Length
8–12 weeks
Receptor desensitisation noted beyond 12 weeks
Break
4–6 weeks
Allow GHS-R1a sensitivity to recover
Monitoring
IGF-1 and cortisol
Monitor cortisol more than with ipamorelin
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of Hexarelin.

1

Hexarelin cardiovascular effects via CD36 receptor — independent of GH

Hexarelin activated CD36 receptors in ventricular cardiomyocytes, reducing ischaemia-reperfusion injury and apoptosis in animal models — effects that were preserved in GH-deficient animals, confirming GH-independent cardiac action.

Circulation, 2003
2

Hexarelin potency compared to GHRP-6 and ipamorelin

Hexarelin produced significantly greater GH release than GHRP-6 or ipamorelin at equivalent doses in human volunteers, with corresponding increases in cortisol and ACTH, confirming its superior but less selective GHS-R1a agonism.

Journal of Clinical Endocrinology and Metabolism, 1997
3

GH secretagogue receptor-independent cardioprotection from hexarelin

GHS-R1a knockout mice retained full cardioprotective response to hexarelin, confirming that cardiac CD36 signalling — not GH release — is the mechanism responsible for hexarelin's cardiac benefits.

Endocrinology, 2006
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
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4★
67%
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M
Matt O.
Calgary, AB · Cardiac Health
★★★★☆
✓ Verified Purchase
Strong GH release, use with caution

Hexarelin is no joke — the GH pulse is noticeably stronger than ipamorelin. I do get some cortisol elevation so I cycle 8 weeks on and 4 off. Good for the cardiac data specifically.

F
Fiona M.
Vancouver, BC · Cardiovascular
★★★★☆
✓ Verified Purchase
Interesting cardio benefits

Using low-dose hexarelin alongside a standard GH stack after reading the CD36 research. Heart rate variability has improved noticeably on my wearable. Cautious but optimistic.

A
Adam R.
Toronto, ON · Performance
★★★★★
✓ Verified Purchase
Potent compound

If you want the strongest GH pulse from a secretagogue, hexarelin delivers. Use shorter cycles and monitor cortisol. Results in body composition at 10 weeks were impressive.

Common Questions

Frequently Asked Questions

Hexarelin produces larger GH pulses but is less selective — it also elevates cortisol, ACTH, and prolactin more than ipamorelin. Hexarelin has the unique addition of CD36-mediated cardioprotective effects absent in ipamorelin.
CD36 is a receptor expressed in cardiac muscle that, when activated by hexarelin, produces direct anti-apoptotic and cardioprotective signalling. This effect is completely independent of GH or IGF-1 and represents a unique secondary mechanism not found in any other GH secretagogue.
GHS-R1a desensitisation occurs more rapidly with potent agonists like hexarelin than with ipamorelin. Cycles of 8-12 weeks with 4-6 week breaks are recommended to maintain GH release efficacy.
Moderately. Hexarelin activates the ghrelin pathway more broadly than ipamorelin, producing more appetite stimulation — though less than GHRP-6. Worth considering if you are managing caloric intake.
Yes. CJC-1295 No DAC plus hexarelin produces the same GHRH/GHS-R1a synergy as CJC/ipamorelin but with larger GH pulses (and more cortisol). Some researchers use this combination for shorter, more aggressive cycles.
Those seeking maximum GH release from a secretagogue, or those with a specific interest in cardiovascular support alongside GH optimisation. For general wellness and longevity, ipamorelin is typically preferred due to its cleaner hormonal profile.
Hexarelin Hexarelin
Price range: $85.00 through $153.00