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Long-Acting GHRH · SubQ 99%+ Purity CJC-1295 With DAC
Longevity Performance

CJC-1295 With DAC

CJC-1295 With DAC — long-acting GHRH analogue that provides sustained GH elevation over 7-10 days from a single weekly injection.

★★★★☆ 4.3 · 36 verified reviews · See all
$158.00
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🚚 Free expedited shipping on orders over $100 CAD · Estimated delivery: 2–4 business days
🔬 Third-Party Tested
🇨🇦 Ships Canada-Wide
📦 Discreet Packaging
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Key Benefits
  • Single weekly injection — 7-10 day half-life from albumin-binding DAC technology
  • Sustained GH and IGF-1 elevation throughout the week
  • Simplest GH secretagogue protocol — one injection weekly
  • Supports body composition, collagen synthesis, and recovery
  • Avoids daily injection burden of short-acting GHRH analogues
Community Insights

Why people research CJC-1295 With DAC

These are the specific situations and goals that lead researchers to CJC-1295 With DAC. For research purposes only.

01
Simpler once-weekly or twice-weekly dosing schedule instead of daily injections
the Drug Affinity Complex extends half-life to multiple days
02
Maintaining continuously elevated GH secretion for chronic fat loss or tissue repair rather than producing isolated daily pulses
03
Reducing injection frequency for people experiencing needle fatigue from multiple daily peptide protocols
04
Pairing with once-weekly tirzepatide for a minimal injection frequency optimisation protocol
two injections per week covering both metabolic and GH axes
05
Using as a cost-effective long-acting GHRH alternative to pharmaceutical HGH with a more manageable logistics burden
06
Sustained overnight and daytime GH elevation for tissue repair without needing to wake for an additional injection
07
Simplifying a complex peptide stack into fewer doses
CJC with DAC once weekly plus a GLP-1 once weekly covers two major axes in two injections
08
Keeping GH levels elevated for extended periods during a muscle-building phase rather than relying on discrete pulses
09
Managing travel and unpredictable schedules
the long-acting version allows dosing flexibility that daily peptides don't permit
10
Running a lower-cost continuous background GH protocol without the expense or regulatory complexity of pharmaceutical somatropin
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 2mg vial + 2mL BAC water
Suggested Cycle Length
8–12 weeks
For research reference only

⚠ For research reference only. CJC-1295 With DAC is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

CJC-1295 With DAC Vial

Your selected amount of lyophilized CJC-1295 With DAC in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How CJC-1295 With DAC Works

The mechanism of action, step by step.

01

Drug Affinity Complex Technology

The lysine-DAC modification in CJC-1295 With DAC covalently binds the peptide to serum albumin after injection, dramatically extending its half-life from 30 minutes to 6-10 days — enabling weekly dosing.

02

Sustained GHRH Receptor Stimulation

Continuous low-level GHRH receptor activation from the albumin-bound depot produces sustained GH release over the dosing interval, elevating mean GH levels and IGF-1 throughout the week.

03

IGF-1 Plateau Maintenance

Weekly dosing maintains IGF-1 in the elevated range without the peaks and troughs of daily injection protocols, which is advantageous for collagen synthesis, cellular repair, and body composition goals.

04

Convenience-Efficacy Balance

The sustained-release mechanism trades the precise pulse control of short-acting analogues for simplicity of dosing, making it appropriate for protocols where weekly compliance is preferred over daily administration.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Typical Dose
1000–2000 mcg
Once weekly
Starting Dose
1000 mcg
Weekly for first 4 weeks
Stack Dose
1000 mcg
Combined with ipamorelin 200-300 mcg daily
Cycle Length
3–6 months
Long cycles suit weekly protocol
Break
6–8 weeks
Allows GH axis recalibration
Monitoring
IGF-1 at 8 weeks
Adjust dose to IGF-1 target
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of CJC-1295 With DAC.

1

CJC-1295 with DAC — dose-dependent GH and IGF-1 elevation in healthy adults

Single injections of CJC-1295 With DAC at doses of 1-2 mg produced sustained GH elevation over 7-10 days and IGF-1 increases of 1.5-3x above baseline in healthy adults, with a benign side-effect profile.

Journal of Clinical Endocrinology and Metabolism, 2006
2

Albumin-binding technology in peptide half-life extension

The DAC modification's covalent albumin binding is quantitatively explained by its 24-hour off-rate from albumin — creating a sustained-release depot that delivers active peptide over the full weekly dosing interval.

Bioconjugate Chemistry, 2004
3

Sustained IGF-1 elevation and body composition in GH-deficient adults

Weekly GHRH analogue therapy producing sustained IGF-1 elevation in the 200-300 ng/mL range resulted in significant lean mass gains and fat loss comparable to daily GH secretagogue protocols over 6 months.

Growth Hormone and IGF Research, 2010
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
5★
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4★
67%
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T
Tom A.
Edmonton, AB · Anti-Aging
★★★★☆
✓ Verified Purchase
Best for people who hate daily injections

Switched from daily CJC No DAC to the weekly protocol. Results are similar and compliance is much easier. IGF-1 stable in the mid-200s at 4 months.

R
Rachel S.
Halifax, NS · Body Composition
★★★★☆
✓ Verified Purchase
Good steady-state IGF-1

Weekly injection keeps IGF-1 elevated all week without the daily routine. Good for collagen and recovery. Sleep is better. Body composition improving slowly.

C
Charles V.
Calgary, AB · Performance
★★★★★
✓ Verified Purchase
Excellent paired with daily ipamorelin

Using CJC-DAC once weekly and ipamorelin 150 mcg nightly. The combination keeps IGF-1 high while the ipamorelin adds nightly GH pulses. Best of both approaches.

Common Questions

Frequently Asked Questions

Neither is categorically better — they suit different protocols. Without DAC produces pulsatile GH matching natural rhythms and may better preserve receptor sensitivity long-term. With DAC provides weekly convenience and sustained baseline IGF-1 elevation. Many researchers use both: CJC-DAC weekly for baseline IGF-1 and ipamorelin nightly for pulsatile GH.
This is a theoretical concern. Some researchers report taking weekend breaks (e.g., 5 on / 2 off) to mitigate potential tachyphylaxis. The clinical significance in the context of weekly dosing protocols remains debated.
1000 mcg (1 mg) weekly is the standard starting dose, matching the Phase 2 clinical trial protocol. Some researchers escalate to 2 mg weekly after 4-6 weeks based on IGF-1 response.
Yes — this is a popular protocol. CJC-DAC provides the GHRH signal (weekly) while daily ipamorelin adds ghrelin-axis GH pulses, particularly at night. The two mechanisms are synergistic.
Water retention is slightly more common with CJC-DAC due to more continuous GH exposure. This is dose-dependent and typically resolves by reducing to 1 mg weekly. Carpal tunnel symptoms are also possible at higher doses.
Subcutaneous injection into the abdomen, upper thigh, or tricep area. Rotate injection sites weekly to prevent lipohypertrophy at a single site.
CJC-1295 With DAC CJC-1295 With DAC
$158.00