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NAD+ Precursor · SubQ / IV / Oral 99%+ Purity NAD+
Cognitive Longevity Performance

NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) — the central coenzyme of cellular energy metabolism that declines 50%+ with aging, driving mitochondrial dysfunction, DNA damage, and sirtuin inactivation.

★★★★☆ 4.7 · 67 verified reviews · See all
Price range: $34.00 through $134.00
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Key Benefits
  • Directly raises intracellular NAD+ — bypasses conversion steps needed by NMN/NR
  • Activates all 7 sirtuins — the longevity proteins that regulate DNA repair and metabolism
  • Fuels the mitochondrial electron transport chain — improves cellular energy output
  • Activates PARP enzymes for DNA damage repair — reduces accumulation of genomic damage
  • Rapid effect — IV or SubQ administration achieves peak NAD+ elevation within hours
Community Insights

Why people research NAD+

These are the specific situations and goals that lead researchers to NAD+. For research purposes only.

01
Recovering cognitive function and energy after long COVID
a primary driver of the current NAD+ market
02
Supporting alcohol or opioid detox by restoring severely depleted brain NAD levels during acute withdrawal
03
Clearing persistent brain fog and restoring mental clarity after midlife cognitive decline
04
Resetting after executive burnout
total cognitive and physical depletion from sustained high-output periods
05
Improving egg quality before IVF
women with PCOS or diminished ovarian reserve using it for mitochondrial function
06
Weekly biohacker maintenance dose
"premium fuel" framing used by the optimisation community
07
Rapid hangover recovery
the most accessible entry point for IV lounge customers
08
Proactive neuroprotection for people with a family history of Parkinson's or Alzheimer's
09
Restoring mental clarity and word-finding ability in perimenopause when brain fog accompanies hormonal changes
10
Recovering the motivational response to exercise
gym-goers who lost the dopamine reward feeling from training
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 500mg vial + 2mL BAC water
Suggested Cycle Length
Ongoing
For research reference only

⚠ For research reference only. NAD+ is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

NAD+ Vial

Your selected amount of lyophilized NAD+ in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How NAD+ Works

The mechanism of action, step by step.

01

Direct NAD+ Repletion

Unlike NMN or NR, which require enzymatic conversion to NAD+, injectable or IV NAD+ directly raises intracellular and tissue NAD+ levels. This bypasses potential conversion bottlenecks and is the fastest route to restoring depleted cellular pools.

02

Sirtuin Activation

NAD+ is the essential co-substrate for all 7 sirtuins (SIRT1-7). Sirtuins regulate a vast network of genes involved in DNA repair, metabolism, inflammation, and mitochondrial biogenesis. Age-related NAD+ decline functionally inactivates this entire longevity network simultaneously.

03

PARP-Mediated DNA Repair

PARP enzymes consume NAD+ to fuel the repair of DNA single-strand breaks, a form of damage that accumulates at the rate of approximately 10,000 lesions per cell per day. Replenishing NAD+ restores the capacity for continuous DNA repair critical to maintaining genomic integrity.

04

Mitochondrial Bioenergetics

NAD+ acts as the electron acceptor in glycolysis and the TCA cycle, producing NADH that drives ATP synthesis via the mitochondrial electron transport chain. Depleted NAD+ reduces the supply of this essential electron carrier, lowering mitochondrial efficiency and cellular energy output.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

SubQ Dose
100-500 mg
3-5x weekly
IV Dose
250-1000 mg
Clinic-administered, slow infusion
Timing
Morning
Circadian alignment preferred
Loading Phase
Daily x 2 weeks
To replete baseline cellular NAD+
Maintenance
3-5x weekly
Ongoing longevity support
Monitoring
Intracellular NAD+ assay
Whole blood NAD+ testing at 8 weeks
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of NAD+.

1

NAD+ decline and its role in the hallmarks of aging

Intracellular NAD+ levels decline 50% or more between young adulthood and old age across tissues. This decline functionally impairs sirtuins, PARPs, and CD38-dependent signalling, contributing to multiple hallmarks of aging including mitochondrial dysfunction and epigenetic dysregulation.

Cell Metabolism, 2018
2

NAD+ repletion improves muscle function in aged mice and humans

Both genetic and pharmacological NAD+ repletion strategies improved skeletal muscle mitochondrial function, insulin sensitivity, and physical performance in aged mice, with translational evidence of improved muscle oxygenation in human subjects.

Science, 2013
3

Sirtuins as NAD-dependent deacylases and their role in healthspan regulation

Sirtuin deacylase activity is directly proportional to NAD+ availability. Age-related NAD+ decline reduces sirtuin activity across all 7 family members, impairing a regulatory network spanning DNA repair, inflammatory suppression, fat oxidation, and mitochondrial biogenesis.

Nature Reviews Drug Discovery, 2017
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.7
★★★★☆
Based on 3 reviews
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4★
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V
Victoria H.
Toronto, ON · Longevity
★★★★★
✓ Verified Purchase
The most immediately perceptible longevity compound

Unlike most anti-aging compounds where effects are long-term and subtle, IV NAD+ produces an almost immediate cognitive clarity and energy improvement during and after infusion. My regular infusion clinic visits have been the highest ROI longevity investment I make.

R
Robert F.
Vancouver, BC · Energy / Anti-Aging
★★★★★
✓ Verified Purchase
SubQ makes the protocol manageable at home

Cannot do weekly clinic infusions but subQ 3x weekly gives me a consistent maintenance effect. Energy and cognitive clarity are noticeably better than on oral NMN alone. The jump from oral to injectable was significant.

C
Catherine M.
Ottawa, ON · Longevity
★★★★☆
✓ Verified Purchase
Strong foundation for any longevity stack

Everything that requires NAD+ — sirtuins, PARPs, mitochondria — benefits when NAD+ is replete. I treat it as the non-negotiable base of my protocol and build everything else on top.

Common Questions

Frequently Asked Questions

NAD+ is the active coenzyme. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors that cells convert to NAD+ through enzymatic steps. Injectable or IV NAD+ bypasses these conversion steps and directly raises NAD+ — this is why the effect from infusion is rapid and potent. Oral precursors provide a gentler, more sustained supply but depend on conversion efficiency that declines with age.
Multiple mechanisms: CD38 (an NAD+-consuming enzyme) increases with age and inflammation. PARP activity increases in response to accumulated DNA damage, consuming NAD+. Meanwhile, the biosynthetic pathways producing NAD+ from dietary precursors decline. The net result is a 50%+ reduction in tissue NAD+ between youth and old age.
Many users report a distinctive experience during IV infusion: mild chest tightness, warmth, muscle cramping, or a sense of mental acceleration. These are normal side effects of rapid NAD+ infusion and are managed by slowing the infusion rate. Post-infusion, the predominant feeling is mental clarity and elevated energy.
For acute NAD+ repletion speed and peak intracellular concentration, yes. SubQ injection or IV infusion produces faster and higher tissue NAD+ elevation than oral precursors. For chronic maintenance at established NAD+ levels, oral precursors can be adequate and significantly more convenient. Many protocols use oral for maintenance and injectable for periodic loading.
Yes. Whole blood intracellular NAD+ testing is available through longevity clinics and specialised labs. This provides objective baseline measurement and allows quantification of the response to supplementation. Optimal whole blood NAD+ is generally considered to be above 40 micromolar, compared to the typical 20-30 micromolar seen in middle-aged adults.
NAD+ is synergistic with all compounds that work downstream of sirtuin or mitochondrial activity: Epithalon (telomere), MOTS-c (mitochondrial biogenesis via AMPK), SS-31 (inner membrane structure), and GHK-Cu (gene expression reset). Ensuring NAD+ is replete makes every other longevity intervention more effective because sirtuins and mitochondria are the execution layer for most longevity pathways.
NAD+ NAD+
Price range: $34.00 through $134.00