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Gonadotropin · SubQ 99%+ Purity HCG (Human Chorionic Gonadotropin)
Hormones Sexual Health

HCG (Human Chorionic Gonadotropin)

HCG (Human Chorionic Gonadotropin) — gonadotropin that directly activates the testicular LH receptor to drive testosterone production and maintain testicular function.

★★★★☆ 4.7 · 44 verified reviews · See all
Price range: $83.00 through $153.00
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Key Benefits
  • Directly stimulates Leydig cells to produce testosterone — the LH analogue
  • Prevents testicular atrophy during TRT or anabolic compound use
  • Restores testosterone production during post-cycle recovery
  • Maintains fertility during testosterone replacement therapy
  • Well-characterised clinical agent used in endocrinology for decades
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
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Based on 5000mg vial + 2mL BAC water
Suggested Cycle Length
Ongoing (as directed)
For research reference only

⚠ For research reference only. HCG (Human Chorionic Gonadotropin) is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

HCG (Human Chorionic Gonadotropin) Vial

Your selected amount of lyophilized HCG (Human Chorionic Gonadotropin) in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How HCG (Human Chorionic Gonadotropin) Works

The mechanism of action, step by step.

01

LH Receptor Activation

HCG is structurally homologous to LH and binds the same receptor on testicular Leydig cells with high affinity. Leydig cell LH receptor activation triggers cAMP/PKA signalling, inducing the StAR protein and CYP enzymes responsible for converting cholesterol to testosterone.

02

Testosterone Production

The cAMP cascade initiated by HCG-LH receptor binding increases expression of steroidogenic acute regulatory (StAR) protein, which transports cholesterol to the inner mitochondrial membrane for conversion to pregnenolone — the rate-limiting step in testosterone biosynthesis.

03

Testicular Volume Maintenance

When the HPG axis is suppressed by exogenous testosterone or anabolic compounds, LH falls to near zero and Leydig cells shrink. HCG prevents this atrophy by providing the LH-equivalent stimulus needed to maintain Leydig cell mass and intratesticular testosterone levels.

04

Sperm Production Support

HCG also activates FSH-independent spermatogenesis pathways via intratesticular testosterone. Men on TRT who want to maintain fertility can use HCG to keep intratesticular testosterone high enough to support ongoing spermatogenesis — a clinically established approach.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Maintenance Dose
250-500 IU
2-3x weekly during TRT
PCT Dose
1000-1500 IU
Every other day x 3 weeks
Fertility Protocol
500-1000 IU
3x weekly under physician guidance
TRT Adjunct
Ongoing 250-500 IU
2-3x weekly co-administration
PCT Protocol
3 weeks
EOD at higher dose, then taper
Monitoring
Total T, LH, testicular volume
Every 6-8 weeks during use
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of HCG (Human Chorionic Gonadotropin).

1

HCG maintains intratesticular testosterone during TRT

Men on testosterone replacement therapy co-administered HCG 500 IU every other day maintained intratesticular testosterone concentrations and spermatogenesis equivalent to normal range, while exogenous testosterone alone suppressed both to near-zero.

Journal of Clinical Endocrinology and Metabolism, 2005
2

HCG stimulation test for Leydig cell reserve assessment

The HCG stimulation test remains the clinical gold standard for assessing Leydig cell functional reserve — the maximal testosterone response to exogenous LH-receptor stimulation — in men with hypogonadism evaluation.

European Journal of Endocrinology, 2010
3

HCG for male infertility in hypogonadotrophic hypogonadism

HCG monotherapy or in combination with FSH produced successful spermatogenesis and assisted reproductive technology outcomes in men with hypogonadotrophic hypogonadism, establishing gonadotropin therapy as the standard of care for this population.

Human Reproduction, 2013
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.7
★★★★☆
Based on 3 reviews
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33%
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R
Robert G.
Vancouver, BC · TRT Optimisation
★★★★★
✓ Verified Purchase
Essential part of my TRT protocol

Running TRT for 3 years. Adding HCG 250 IU 3x weekly eliminated the testicular atrophy and maintained the physical feel of normal function. Would not run TRT without it.

B
Brandon K.
Toronto, ON · Post-Cycle Recovery
★★★★★
✓ Verified Purchase
Fast PCT recovery confirmed by bloodwork

Used HCG EOD at 1500 IU for 3 weeks followed by nolvadex. Testosterone was back to 480 ng/dL at week 5 post-cycle. The fastest recovery I have had.

C
Chris L.
Calgary, AB · Hormonal Health
★★★★☆
✓ Verified Purchase
Reliable and well studied

Unlike some of the more experimental compounds, HCG has 60 years of clinical use. The predictability of response is excellent. Testicular function maintained throughout a long TRT protocol.

Common Questions

Frequently Asked Questions

It depends on your goals. TRT alone significantly suppresses LH, leading to testicular atrophy, reduced intratesticular testosterone (which is 50-100x higher than serum T and required for sperm production), and reduced fertility. If testicular function and fertility matter to you, HCG co-administration is strongly recommended. If not, TRT monotherapy is adequate for hormonal replacement.
HCG and LH bind the same receptor with similar affinity. HCG has a much longer half-life (24-36 hours vs 30 minutes for LH), making it practical as an injected pharmaceutical. The longer half-life also means HCG produces sustained, non-pulsatile LH-receptor stimulation — different from natural pulsatile LH but sufficient for testosterone production and Leydig cell maintenance.
Yes. By stimulating testosterone production, HCG also indirectly increases aromatisation to oestradiol. Men prone to oestrogen-related side effects (water retention, gynecomastia) may need to monitor E2 and consider aromatase inhibitor support. This is managed the same way as TRT-related oestrogen elevation.
LH receptor activation by HCG produces a measurable testosterone rise within 24-48 hours. At standard doses (250-500 IU), steady-state testosterone support is typically established within 1-2 weeks. In PCT protocols, the higher dose (1000-1500 IU) produces more rapid axis stimulation.
Yes. HCG is extensively used in female fertility protocols where it triggers ovulation by mimicking the LH surge. It is also used in weight loss protocols (as a compounded injectable with VLCD diets) though evidence for the weight loss application is inconsistent.
The HCG stimulation test — a clinical diagnostic — directly assesses Leydig cell reserve. If maximum-dose HCG fails to produce a meaningful testosterone response, primary testicular failure is indicated and gonadotropin therapy alone will not restore function. TRT would then be the appropriate management.
HCG (Human Chorionic Gonadotropin) HCG (Human Chorionic Gonadotropin)
Price range: $83.00 through $153.00