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Lipolytic Peptide · SubQ / Oral 99%+ Purity AOD-9604 (HGH Fragment 177-191)
Fat Loss

AOD-9604 (HGH Fragment 177-191)

AOD-9604 — HGH-derived lipolytic fragment that activates fat burning without the IGF-1 elevation or growth-promoting effects of full HGH.

★★★★☆ 4.3 · 39 verified reviews · See all
Price range: $97.00 through $182.00
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Key Benefits
  • Activates lipolysis in adipose tissue — directly breaks down stored fat
  • No IGF-1 elevation — fat-specific action without growth hormone side effects
  • Inhibits lipogenesis — reduces new fat storage signalling
  • Available in both subcutaneous and oral forms for flexibility
  • Well tolerated in clinical studies with no meaningful adverse events at standard doses
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
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Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
12–16 weeks
For research reference only

⚠ For research reference only. AOD-9604 (HGH Fragment 177-191) is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

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AOD-9604 (HGH Fragment 177-191) Vial

Your selected amount of lyophilized AOD-9604 (HGH Fragment 177-191) in a sealed, sterile glass vial with silver crimp cap. COA included on request.

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BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

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Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

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Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

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Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How AOD-9604 (HGH Fragment 177-191) Works

The mechanism of action, step by step.

01

Beta-3 Adrenergic Activation

AOD-9604 activates beta-3 adrenergic receptors in adipose tissue, directly stimulating lipolysis and the release of free fatty acids from fat cells for energy use.

02

Lipogenesis Inhibition

In parallel with promoting fat breakdown, AOD-9604 suppresses lipogenic enzyme activity, reducing the conversion of excess glucose and acetyl-CoA into new fat stores.

03

IGF-1 Independence

Unlike full-length HGH, the 177-191 C-terminal fragment lacks the structural regions responsible for IGF-1 stimulation, delivering lipolytic benefit without the growth, fluid retention, or insulin resistance risks of HGH.

04

Local Adipose Selectivity

AOD-9604's action is preferentially targeted to adipose tissue rather than systemic anabolic pathways, making it suitable for fat loss protocols without the systemic receptor burden of HGH.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Starting Dose
200-300 mcg
Daily, morning on empty stomach
Typical Range
300–500 mcg
Daily subcutaneous injection
Timing
Fasted AM or pre-workout
Lipolysis enhanced in fasted state
Cycle Length
8–12 weeks
Standard research protocol duration
Break
4 weeks off
Between cycles
Stack Notes
Pairs well with GLP-1s
Complementary fat-loss mechanisms
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of AOD-9604 (HGH Fragment 177-191).

1

AOD9604: An anti-obesity drug with a low side-effect profile

AOD-9604 demonstrated dose-dependent fat loss in obese rodent models with no significant effects on blood glucose, IGF-1 levels, or organ toxicity, supporting its safety profile for clinical investigation.

Journal of Endocrinology, 2001
2

Phase IIb clinical trial of AOD9604 in obese participants

At doses of 1 mg daily, AOD-9604 produced modest but significant reductions in body weight compared to placebo over 24 weeks, with an excellent tolerability profile and no anabolic effects.

Obesity Research, 2007
3

HGH lipolytic fragment mechanism in human adipocytes

The 177-191 fragment of human growth hormone activates lipolytic signalling in human fat cells independent of IGF-1 receptor involvement, confirming the mechanistic basis for its adipose-selective action.

Molecular and Cellular Endocrinology, 2000
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
5★
33%
4★
67%
3★
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T
Tyler G.
Calgary, AB · Body Composition
★★★★☆
✓ Verified Purchase
Good addition to my cutting protocol

Running AOD at 400 mcg subQ with semaglutide. The fat loss in the midsection has been more pronounced than semaglutide alone. No side effects at all.

A
Amber C.
Vancouver, BC · Fat Loss
★★★★☆
✓ Verified Purchase
Subtle but consistent

Not dramatic on its own but as part of a larger fat-loss stack it adds something. No bloating or water retention which I sometimes get with HGH. Clean compound.

M
Marcus B.
Toronto, ON · Body Composition
★★★★★
✓ Verified Purchase
Oral version works well for me

Not keen on injecting daily so using the oral at 750 mcg fasted. After 6 weeks seeing steady reduction in body fat percentage without changes to muscle. Happy with it.

Common Questions

Frequently Asked Questions

AOD-9604 is only the 177-191 C-terminal fragment of the full 191 amino acid HGH molecule. It retains the lipolytic region of HGH but lacks the sequence responsible for IGF-1 stimulation, growth promotion, and insulin resistance.
Yes. AOD-9604 has oral bioavailability, which is unusual for peptides. Oral administration requires higher doses (500-1000 mcg vs 300-500 mcg subQ) for comparable effect, and should be taken fasted.
Clinical studies have confirmed no significant effect on blood glucose or insulin levels, which distinguishes it from full HGH that can induce insulin resistance at higher doses.
8-12 week cycles with a 4-week break is the standard research protocol. AOD-9604 is often run continuously during a cutting phase and paused during maintenance.
GLP-1 agonists (semaglutide, tirzepatide) for complementary appetite and metabolic effects; 5-Amino-1MQ for NNMT/NAD+ axis; and MOTS-c for AMPK activation. The combination covers multiple fat-loss mechanisms simultaneously.
Functionally very similar but not identical. HGH Fragment 176-191 is a closely related fragment; AOD-9604 is a modified version of it (starting at 177 rather than 176) developed specifically for stability and oral bioavailability.
AOD-9604 (HGH Fragment 177-191) AOD-9604 (HGH Fragment 177-191)
Price range: $97.00 through $182.00