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Anti-Obesity Peptide · SubQ 99%+ Purity Adipotide
Fat Loss

Adipotide

Adipotide — a first-in-class peptidomimetic that targets the vasculature feeding adipose tissue, inducing apoptosis of fat-supporting blood vessels.

★★★★☆ 4.3 · 19 verified reviews · See all
Price range: $90.00 through $170.00
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Key Benefits
  • Targets prohibitin on adipose endothelium — destroys fat's blood supply
  • Primate studies: 11% body weight reduction in 28 days at research doses
  • Preferential action on visceral and subcutaneous white adipose tissue
  • Distinct mechanism from all GLP-1, NNMT, and hormonal fat-loss agents
  • Potential for sustained fat loss with short treatment cycles
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
4–6 weeks
For research reference only

⚠ For research reference only. Adipotide is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

Adipotide Vial

Your selected amount of lyophilized Adipotide in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How Adipotide Works

The mechanism of action, step by step.

01

Prohibitin-Mediated Targeting

Adipotide contains a targeting domain that binds prohibitin — a protein overexpressed on the luminal surface of blood vessels supplying white adipose tissue — delivering its pro-apoptotic payload selectively to fat vasculature.

02

Adipose Vascular Apoptosis

Once bound to prohibitin-expressing endothelial cells, adipotide triggers apoptosis of the blood vessels that feed fat tissue. Deprived of its blood supply, the adipose depot undergoes cell death and resorption.

03

Selective Adipose Targeting

Because prohibitin expression on vasculature is substantially higher in adipose tissue than in other organs, adipotide's cytotoxic action is preferentially directed at fat rather than lean tissue.

04

Metabolic Improvement Secondary to Fat Loss

Adipose tissue reduction secondary to vascular ablation produces downstream improvements in insulin sensitivity, leptin levels, and systemic inflammation — consistent with beneficial effects of visceral fat reduction by any mechanism.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Research Dose
100–250 mcg/kg
Daily subQ — based on primate protocols
Cycle Length
4 weeks
Short cycles used in published research
Monitoring
Kidney function
Monitor creatinine — renal effects seen at high doses in primates
Cycle
4 weeks on
Followed by extended break
Break
8–12 weeks
Allow tissue recovery between cycles
Monitoring
Kidney markers
Essential — renal burden observed in primate studies
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of Adipotide.

1

Targeted vascular deletion ablates adipose tissue in obese mice

Adipotide selectively killed adipose endothelial cells expressing prohibitin in obese mice, producing rapid and sustained reduction in fat mass with restoration of insulin sensitivity without systemic toxicity at low doses.

Science, 2004
2

Adipotide causes rapid weight loss and improved insulin sensitivity in obese monkeys

Obese rhesus monkeys treated with adipotide for 28 days showed 11% body weight reduction, 27% reduction in waist circumference, and significant improvement in insulin resistance, with reversible renal effects at higher doses.

Science Translational Medicine, 2011
3

Prohibitin as a vascular address for targeted anti-obesity therapy

Prohibitin is expressed at high levels on the luminal surface of adipose vasculature in obese subjects but not in lean controls, validating it as a selective molecular address for fat-targeted therapeutic delivery.

Nature Medicine, 2010
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
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4★
67%
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R
Robert H.
Vancouver, BC · Research
★★★★☆
✓ Verified Purchase
Unique mechanism unlike anything else

Researching this specifically because of the vascular mechanism — nothing else works this way. Early results at 3 weeks show visible reduction. Monitoring kidney markers carefully as literature suggests.

C
Carla M.
Toronto, ON · Fat Loss
★★★★☆
✓ Verified Purchase
Promising early results

2 weeks in at conservative doses. Waist measurement is down 1.5 inches already. Will continue monitoring and report back. The mechanism is fascinating scientifically.

A
Alan T.
Calgary, AB · Visceral Fat
★★★★★
✓ Verified Purchase
Best for stubborn visceral fat

Have tried multiple approaches for visceral fat. Adipotide at 4 weeks produced the most visible reduction in abdominal fullness I have seen. Blood work at week 4 was fine.

Common Questions

Frequently Asked Questions

Unlike appetite suppressants or metabolic enhancers, adipotide destroys the blood vessels that feed fat tissue. It targets prohibitin — a protein on the surface of adipose blood vessel cells — and triggers their apoptosis, cutting off fat depots from their nutrient supply.
In obese rhesus monkeys, 28 days of adipotide produced 11% body weight reduction, 27% waist circumference reduction, and significant insulin sensitivity improvement — results achieved faster than any GLP-1 agent at comparable timepoints.
At higher doses in primates, reversible renal effects were observed. Kidney function monitoring (creatinine, BUN) is essential during any adipotide research protocol. Conservative dosing and short cycles are strongly recommended.
Published primate protocols use 28-day cycles. Extended breaks of 8-12 weeks between cycles are advisable to allow tissue recovery and renal function assessment.
Phase 1 human trials have been conducted. As of the knowledge cutoff, it has not advanced to Phase 3. Poptides supplies it for research purposes.
Mechanistically complementary — GLP-1 agents reduce intake while adipotide targets existing fat depots directly. However, stacking should be approached conservatively given adipotide's novel mechanism and the need for close monitoring.
Adipotide Adipotide
Price range: $90.00 through $170.00