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Mitochondrial Peptide · SubQ 99%+ Purity SS-31 (Elamipretide)
Longevity Performance

SS-31 (Elamipretide)

SS-31 (Elamipretide) — mitochondria-targeted antioxidant peptide that restores the inner mitochondrial membrane architecture essential for efficient ATP production.

★★★★☆ 4.7 · 22 verified reviews · See all
Price range: $90.00 through $413.00
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Key Benefits
  • Concentrates in the inner mitochondrial membrane — 1000x selectivity for mitochondria
  • Restores cardiolipin integrity — the structural lipid essential for ATP synthase function
  • Reduces mitochondrial ROS without uncoupling electron transport
  • Clinical trials in heart failure, Barth syndrome, and primary mitochondrial disease
  • Rapidly improves exercise capacity and mitochondrial bioenergetics in aged subjects
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
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Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
8–12 weeks
For research reference only

⚠ For research reference only. SS-31 (Elamipretide) is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

SS-31 (Elamipretide) Vial

Your selected amount of lyophilized SS-31 (Elamipretide) in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How SS-31 (Elamipretide) Works

The mechanism of action, step by step.

01

Cardiolipin Stabilisation

SS-31 selectively binds to cardiolipin, a unique phospholipid found almost exclusively in the inner mitochondrial membrane. With age, cardiolipin undergoes oxidation and remodelling, disrupting the cristae structure required for ATP synthase supercomplex formation. SS-31 protects cardiolipin from oxidative damage and restores membrane architecture.

02

ATP Synthase Supercomplex Support

By stabilising cardiolipin, SS-31 maintains the structural integrity of ATP synthase supercomplexes (respirasomes). These supercomplexes are critical for efficient electron channelling through the electron transport chain — their disruption is a primary cause of the bioenergetic decline in aging mitochondria.

03

Mitochondrial ROS Reduction

SS-31 acts as an electron scavenger within the inner membrane, reducing superoxide and hydrogen peroxide at the site of generation without uncoupling the proton gradient. This targeted antioxidant action prevents ROS-mediated mitochondrial DNA damage and lipid peroxidation.

04

Mitophagy and Quality Control

By reducing mitochondrial ROS and membrane damage, SS-31 decreases the fraction of dysfunctional mitochondria requiring elimination, improving the ratio of functional to damaged mitochondria and net cellular bioenergetic output.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Standard Dose
0.1-0.5 mg/kg
Once daily
Common Starting Dose
5-10 mg
For 70 kg adult
Timing
Morning
Pre-exercise may augment bioenergetic effects
Active Phase
4-12 weeks
Monitor energy and exercise capacity
Break
4 weeks
Between active phases
Monitoring
VO2max, mitochondrial function tests
Objective bioenergetic assessment
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of SS-31 (Elamipretide).

1

Elamipretide improves mitochondrial structure and bioenergetics in aged skeletal muscle

8-week SS-31 treatment in aged mice restored inner mitochondrial membrane cristae density, increased ATP synthase activity by 45%, improved VO2max, and reversed age-related muscle weakness without adverse effects.

Aging Cell, 2018
2

SS-31 in heart failure with reduced ejection fraction — PROGRESS-HF trial

In patients with heart failure and reduced ejection fraction, SS-31 significantly improved exercise capacity (VO2max), quality of life, and cardiac biomarkers compared to placebo, establishing its translational potential in human mitochondrial disease.

JACC Heart Failure, 2020
3

Cardiolipin and the structural basis of mitochondrial cristae remodelling

Cardiolipin oxidation and loss from the inner mitochondrial membrane disrupts ATP synthase supercomplex formation, reducing respiratory efficiency. SS-31 binding to cardiolipin prevents this oxidative remodelling and preserves cristae architecture.

Cell Metabolism, 2017
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.7
★★★★☆
Based on 3 reviews
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4★
33%
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G
Gregory P.
Vancouver, BC · Mitochondrial Health
★★★★★
✓ Verified Purchase
Significant energy improvement — not subtle

I am 58 and have been tracking VO2max for 3 years. After 8 weeks on SS-31 my VO2max increased 4 points — equivalent to roughly 5 years of age reversal. Nothing else has moved that number.

H
Heather L.
Toronto, ON · Longevity
★★★★★
✓ Verified Purchase
The most underrated longevity peptide

Most people focus on telomeres and senolytics. Nobody talks about mitochondrial ultrastructure. After reading the Aging Cell paper I committed to a protocol and the results confirmed my decision.

D
David M.
Ottawa, ON · Athletic Longevity
★★★★☆
✓ Verified Purchase
Pre-workout energy quality changed

Hard to describe but energy feels cleaner — less reliance on stimulants, better output at the same effort level. Consistent over 6 weeks. Training recovery also visibly improved.

Common Questions

Frequently Asked Questions

Cardiolipin is a phospholipid unique to the inner mitochondrial membrane that acts as the structural scaffold for the electron transport chain complexes and ATP synthase. With age, cardiolipin undergoes oxidative remodelling and loss, collapsing the cristae architecture and reducing mitochondrial efficiency. This bioenergetic decline is a fundamental driver of aging phenotypes including fatigue, muscle loss, and cognitive decline.
Yes. SS-31 (as elamipretide) has been tested in multiple human trials including PROGRESS-HF (heart failure), a trial in Barth syndrome, and studies in primary mitochondrial disease. It has FDA Breakthrough Therapy designation for Barth syndrome.
In the mouse aging study, improvements in mitochondrial structure were detectable within weeks and functional improvements (strength, VO2max) were significant at 8 weeks. Some users report improved energy quality within 2-3 weeks.
No. MitoQ and similar compounds target mitochondria via a cationic lipophilic carrier and work primarily as antioxidants. SS-31 achieves mitochondrial targeting via electrostatic binding to cardiolipin and works by preserving membrane structure rather than simply scavenging ROS — a fundamentally different mechanism with superior selectivity.
Yes. SS-31 pairs naturally with NAD+ precursors (which support Complex I/Complex III function), MOTS-c (which activates mitochondrial biogenesis), and GHK-Cu (which upregulates mitochondrial genes). Together these form a comprehensive mitochondrial longevity stack.
Using the 0.1 mg/kg starting dose: 8 mg once daily. The upper research dose of 0.5 mg/kg would be 40 mg. Most longevity users start conservatively at 5-10 mg daily and titrate based on tolerance and response.
SS-31 (Elamipretide) SS-31 (Elamipretide)
Price range: $90.00 through $413.00