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IGF-1 Analogue · SubQ 99%+ Purity IGF-1 LR3
Performance Recovery

IGF-1 LR3

IGF-1 LR3 — long-acting IGF-1 analogue that bypasses IGF-binding proteins to drive muscle satellite cell activation, protein synthesis, and anabolism.

★★★★☆ 4.3 · 38 verified reviews · See all
Price range: $44.00 through $182.00
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🇨🇦 Ships Canada-Wide
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Key Benefits
  • 70+ hour half-life — sustained IGF-1 signalling vs 15-hour native IGF-1
  • Does not bind IGF-binding proteins — full receptor exposure without protein sequestration
  • Activates muscle satellite cells — promotes hyperplasia alongside hypertrophy
  • Supports nutrient partitioning — drives amino acids and glucose into muscle
  • Systemically active — affects both local injection site and distant muscle tissue
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 1mg vial + 2mL BAC water
Suggested Cycle Length
4–6 weeks
For research reference only

⚠ For research reference only. IGF-1 LR3 is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

IGF-1 LR3 Vial

Your selected amount of lyophilized IGF-1 LR3 in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How IGF-1 LR3 Works

The mechanism of action, step by step.

01

IGF-1R Activation

IGF-1 LR3 binds and activates the IGF-1 receptor (IGF-1R), triggering PI3K/Akt/mTOR and MAPK/ERK signalling pathways — the primary intracellular cascades driving muscle protein synthesis and cell proliferation.

02

IGFBP Avoidance

The arginine-3 substitution in LR3 reduces binding affinity for IGF-binding proteins (IGFBPs) by 100-fold, meaning virtually all circulating IGF-1 LR3 remains free and biologically active — dramatically increasing effective bioavailability.

03

Satellite Cell Activation

IGF-1 LR3 stimulates quiescent muscle satellite cells to proliferate and differentiate into myoblasts, potentially increasing the number of myonuclei in muscle tissue — a mechanism associated with long-term capacity for hypertrophy.

04

Nutrient Partitioning

Systemic IGF-1R activation enhances glucose transporter expression and amino acid uptake in skeletal muscle, directing nutrients toward muscle protein synthesis and away from adipose storage.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Starting Dose
20–40 mcg
Daily or post-workout
Typical Range
40–80 mcg
Adjusted to tolerance
Timing
Post-workout
Leverage muscle insulin sensitivity window
Cycle Length
4–6 weeks
Shorter cycles recommended due to receptor sensitivity
Break
4–6 weeks
Allow IGF-1R sensitivity to reset
Monitoring
Blood glucose
Monitor hypoglycaemia risk, especially fasted
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of IGF-1 LR3.

1

Long R3 IGF-1 binding to IGFBPs and receptor affinity

IGF-1 LR3 demonstrated 100-fold reduced binding to all six IGF-binding proteins compared to native IGF-1, with retained full IGF-1 receptor affinity — predicting dramatically increased bioavailability and prolonged biological activity in vivo.

Journal of Biological Chemistry, 1992
2

IGF-1 LR3 stimulation of satellite cell proliferation in skeletal muscle

Systemic IGF-1 LR3 treatment activated quiescent satellite cells and promoted their differentiation into myoblasts in skeletal muscle tissue, supporting a role in increasing myonuclear number and long-term hypertrophic capacity.

Journal of Applied Physiology, 2003
3

IGF-1 analogue nutrient partitioning and muscle protein synthesis

IGF-1 LR3 enhanced post-exercise muscle protein synthesis rate and glucose uptake in a dose-dependent manner, with greater effect than equimolar native IGF-1 attributable to IGFBP-independent free-receptor engagement.

American Journal of Physiology, 2000
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
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4★
67%
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T
Tyler A.
Calgary, AB · Muscle Gain
★★★★★
✓ Verified Purchase
Significant lean mass gains

Six-week cycle at 60 mcg post-workout. Gained 4 lbs of lean mass while body fat dropped slightly. Nutrient partitioning effect is real — everything I eat seems to go to muscle.

R
Ryan K.
Vancouver, BC · Body Composition
★★★★☆
✓ Verified Purchase
Monitor blood sugar carefully

Excellent compound but IGF-1 LR3 dropped my blood sugar low on a few occasions when I trained fasted. Now inject post-meal and it is fine. Great results at 40 mcg daily.

D
Dean W.
Toronto, ON · Muscle Gain
★★★★☆
✓ Verified Purchase
Best during a bulk

Running this during a caloric surplus and the muscle-to-fat ratio of weight gain is noticeably better than without. Shorter cycles than with HGH peptides — 4 weeks on, 4 off.

Common Questions

Frequently Asked Questions

The arginine-3 substitution and N-terminal 13-amino acid extension reduce IGFBP binding affinity by 100-fold, meaning virtually all LR3 circulates as free, biologically active peptide. This gives it a 70-120 hour half-life versus 15 hours for native IGF-1 and far greater effective bioavailability.
Yes — IGF-1R activation increases glucose uptake in muscle and other tissues. Training fasted while using IGF-1 LR3 carries a real hypoglycaemia risk. Post-workout injection alongside a carbohydrate-containing meal is strongly recommended.
Extended IGF-1R stimulation can lead to receptor downregulation, reducing the anabolic response over time. 4-6 week cycles with equal breaks maintain receptor sensitivity and prevent tachyphylaxis.
Unlike IGF-1 DES (which has preferential local action), IGF-1 LR3 is biologically active systemically regardless of injection site. Most researchers inject subcutaneously in the abdomen or thigh post-workout.
Yes, but with caution. Both HGH (via IGF-1 elevation) and direct IGF-1 LR3 activate the same downstream pathways. Combining them amplifies IGF-1R stimulation and increases both anabolic effects and hypoglycaemia risk — dose management is critical.
Elevated IGF-1 signalling is associated with increased cell proliferation in research models. Long-term safety in healthy adults is not established. Short cycles at conservative doses, and avoiding use in individuals with personal or family history of IGF-1-sensitive cancers, is advisable.
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Price range: $44.00 through $182.00