Home Shop Science About View Cart →
Home › Recovery › KPV (Lysine-Proline-Valine)
Anti-Inflammatory Peptide · Oral / SubQ 99%+ Purity KPV (Lysine-Proline-Valine)
Immune Recovery

KPV (Lysine-Proline-Valine)

KPV — alpha-MSH-derived tripeptide with potent anti-inflammatory action via NF-kB inhibition and mTOR modulation, particularly effective for gut and skin conditions.

★★★★☆ 4.7 · 33 verified reviews · See all
$70.00
Clear
🚚 Free expedited shipping on orders over $100 CAD · Estimated delivery: 2–4 business days
🔬 Third-Party Tested
🇨🇦 Ships Canada-Wide
📦 Discreet Packaging
🛡 Satisfaction Guarantee
Key Benefits
  • Inhibits NF-kB directly — reduces TNF-alpha, IL-1beta, and IL-6 production
  • Anti-inflammatory without immunosuppression — does not impair pathogen defence
  • Effective orally — survives gut transit and reduces intestinal inflammation
  • Modulates mTOR pathway — reduces cellular stress and autophagy dysregulation
  • Derived from alpha-MSH — well-studied natural anti-inflammatory signalling origin
Community Insights

Why people research KPV (Lysine-Proline-Valine)

These are the specific situations and goals that lead researchers to KPV (Lysine-Proline-Valine). For research purposes only.

01
Managing IBD flare-ups
KPV is the C-terminal tripeptide of α-MSH with potent anti-inflammatory action specifically in the gut epithelium
02
Healing intestinal permeability and leaky gut when dietary intervention and probiotics have been insufficient to restore barrier integrity
03
Treating active Crohn's disease or ulcerative colitis flares as an adjunct alongside existing medication
04
Reducing skin inflammation from eczema or psoriasis or contact dermatitis
applied topically or subcutaneously based on the target
05
Stacking with BPC-157 for comprehensive gut healing
KPV handles the inflammatory driver while BPC-157 repairs the gut lining structure
06
Managing IBD symptoms during dietary indiscretion or a stress-triggered flare without adjusting the primary medication
07
Reducing systemic inflammation in autoimmune conditions
the anti-cytokine properties of α-MSH fragments work beyond the gut
08
Healing wounds with significant inflammatory involvement
KPV reduces the inflammatory phase to allow the proliferative healing phase to proceed
09
Supporting gut recovery after alcohol-related intestinal damage alongside abstinence or harm reduction efforts
10
Adding an anti-inflammatory signal to a healing stack alongside BPC-157 and TB-500 and GHK-Cu to address inflammation as well as structural repair
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
4–8 weeks
For research reference only

⚠ For research reference only. KPV (Lysine-Proline-Valine) is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

KPV (Lysine-Proline-Valine) Vial

Your selected amount of lyophilized KPV (Lysine-Proline-Valine) in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How KPV (Lysine-Proline-Valine) Works

The mechanism of action, step by step.

01

NF-kB Inhibition

KPV directly inhibits nuclear factor kappa-B (NF-kB) — the master transcription factor for pro-inflammatory cytokine production. This reduces TNF-alpha, IL-1beta, IL-6, and IL-8 without broadly suppressing immune function.

02

mTOR Pathway Modulation

KPV modulates mTOR signalling in intestinal epithelial and immune cells, reducing inflammatory autophagy dysregulation that contributes to chronic gut conditions including Crohn's disease and ulcerative colitis.

03

Intestinal Epithelial Protection

KPV reduces inflammatory cell invasion of intestinal epithelial tissue and supports barrier function by decreasing pro-inflammatory cytokine production at the mucosal level — particularly relevant for inflammatory bowel conditions.

04

Systemic Anti-inflammatory Action

When administered subcutaneously, KPV produces systemic anti-inflammatory effects, with research demonstrating reduced inflammatory markers in skin, joint, and systemic inflammatory models — extending utility beyond the gut.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

SubQ Dose
250–500 mcg
Once to twice daily
Skin Conditions
250 mcg
Can also apply topically in some protocols
Timing
Flexible
Less timing-sensitive than GH peptides
Acute Inflammatory
8–12 weeks
Full course for gut or skin conditions
Maintenance
Ongoing
Low dose 250 mcg daily tolerated long-term
Stack Note
Pairs with BPC-157
Complementary gut healing mechanisms
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of KPV (Lysine-Proline-Valine).

1

KPV anti-inflammatory mechanism via NF-kB inhibition

KPV tripeptide inhibited NF-kB nuclear translocation in macrophages and intestinal epithelial cells, reducing production of all major pro-inflammatory cytokines without affecting anti-pathogen immune responses — distinguishing it from immunosuppressive agents.

Journal of Immunology, 2004
2

Oral KPV in experimental colitis models

Oral KPV reduced colonic inflammation scores, prevented weight loss, and preserved mucosal integrity in multiple experimental colitis models, with mTOR pathway inhibition identified as a key mechanism for intestinal anti-inflammatory action.

Gastroenterology, 2008
3

Alpha-MSH derived peptides and systemic anti-inflammatory signalling

KPV, derived from the C-terminal tripeptide of alpha-MSH, produced anti-inflammatory effects equivalent to alpha-MSH itself in systemic inflammatory models while offering improved stability and simpler synthesis — supporting development as a standalone anti-inflammatory peptide.

European Journal of Pharmacology, 2001
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.7
★★★★☆
Based on 3 reviews
5★
67%
4★
33%
3★
0%
2★
0%
1★
0%
L
Linda F.
Toronto, ON · Gut Health
★★★★★
✓ Verified Purchase
Transformed my gut health

Years of Crohn's-related inflammation. Added KPV oral 500 mcg twice daily alongside BPC-157. Within 6 weeks the inflammatory markers on my blood work dropped significantly. Symptoms much improved.

R
Rachel A.
Vancouver, BC · Skin Health
★★★★★
✓ Verified Purchase
Great for skin inflammation too

Using KPV for psoriasis alongside standard treatment. The combination of subQ and topical KPV has reduced flare-ups noticeably. Mild, well tolerated, and clearly doing something.

C
Colin R.
Ottawa, ON · Recovery
★★★★☆
✓ Verified Purchase
Part of my BBKG80 stack

Running KPV as part of a broader healing stack. The anti-inflammatory effect is real and the gut tolerance is excellent — even for someone with a sensitive digestive system.

Common Questions

Frequently Asked Questions

KPV (Lysine-Proline-Valine) is the C-terminal tripeptide of alpha-MSH (alpha-melanocyte stimulating hormone). Alpha-MSH is a naturally occurring anti-inflammatory neuropeptide; KPV is its smallest biologically active fragment, retaining the full anti-inflammatory mechanism.
Yes — KPV is one of the few peptides with confirmed oral activity. Its small size (3 amino acids) allows sufficient gut absorption to produce meaningful local and systemic effects. Oral KPV is particularly rational for gut conditions.
BPC-157 primarily heals gut tissue through angiogenesis and growth factor upregulation — it is more tissue-regenerative. KPV is more anti-inflammatory — it directly suppresses the cytokine cascade driving intestinal inflammation. They are complementary and are often used together.
No. KPV selectively inhibits NF-kB-driven pro-inflammatory cytokine production without meaningfully impairing anti-pathogen immune responses. This is mechanistically distinct from corticosteroids or biologics that broadly suppress immunity.
Researchers using KPV for IBD or gut inflammation typically report initial improvement within 2-4 weeks, with more substantial changes by weeks 8-12 of consistent oral use.
Inflammatory bowel conditions (Crohn's, ulcerative colitis), leaky gut and IBS, inflammatory skin conditions (psoriasis, eczema), and systemic inflammation reduction in the context of post-training recovery or chronic inflammatory states.
KPV (Lysine-Proline-Valine) KPV (Lysine-Proline-Valine)
$70.00