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Exercise Mimetic · SubQ 99%+ Purity SLU-PP-322
Fat Loss Longevity Performance

SLU-PP-322

SLU-PP-322 — ERR alpha/gamma agonist that mimics the molecular signature of aerobic exercise, driving fat oxidation and mitochondrial gene expression without receptor desensitisation.

★★★★☆ 4.3 · 19 verified reviews · See all
$92.00
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Key Benefits
  • Activates ERR-alpha and ERR-gamma — the nuclear receptors governing aerobic exercise gene expression
  • Drives fat oxidation independent of AMPK — a complementary pathway to AICAR/MOTS-c
  • Upregulates mitochondrial biogenesis and oxidative enzyme expression
  • Improves running endurance and reduces fat mass in preclinical models
  • Novel mechanism — does not share tolerance or downregulation profile with AMPK activators
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
4–8 weeks
For research reference only

⚠ For research reference only. SLU-PP-322 is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

SLU-PP-322 Vial

Your selected amount of lyophilized SLU-PP-322 in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How SLU-PP-322 Works

The mechanism of action, step by step.

01

ERR-alpha/gamma Agonism

SLU-PP-322 binds and activates Estrogen-Related Receptors alpha and gamma (ERR-alpha, ERR-gamma) — nuclear receptor transcription factors that regulate the expression of genes governing mitochondrial oxidative phosphorylation, fatty acid oxidation, and aerobic exercise adaptation.

02

PGC-1alpha Transcriptional Co-activation

ERR-alpha and ERR-gamma are the primary downstream partners of PGC-1alpha, the master regulator of mitochondrial biogenesis. SLU-PP-322 activates these receptors in a way that mimics the PGC-1alpha signalling produced by endurance exercise, driving an authentic aerobic gene expression program.

03

Fat Oxidation Enzyme Upregulation

ERR activation increases expression of key fat oxidation enzymes including CPT-1, HADHA, and ACADM. These regulate the transport and beta-oxidation of long-chain fatty acids in mitochondria — the fundamental molecular basis for improved fat burning capacity.

04

Complementary to AMPK Pathway

AICAR and MOTS-c work upstream through AMPK. SLU-PP-322 works downstream at the nuclear receptor level where exercise gene programs are transcribed. Combining them addresses both the cellular energy sensor (upstream) and the gene expression effector (downstream) — potentially synergistic for endurance and metabolic adaptation.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Research Dose
2-10 mg/kg
Once daily (based on preclinical data)
Human Estimate
50-200 mg
Allometric scaling from mouse data
Timing
Pre-workout
Prior to endurance training
Active Phase
4-8 weeks
With monitoring
Break
4 weeks
Between cycles
Stack
AICAR / MOTS-c
Complementary AMPK + ERR activation
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of SLU-PP-322.

1

SLU-PP-322 activates ERR-alpha/gamma and mimics aerobic exercise gene signature

SLU-PP-322 activated ERR-alpha and ERR-gamma transcriptional programs in skeletal muscle, producing gene expression changes that closely mirrored those induced by endurance exercise training, including upregulation of mitochondrial biogenesis and fatty acid oxidation pathways.

Nature Chemical Biology, 2023
2

ERR agonist improves running endurance and reduces adiposity in mice

Mice treated with an ERR-alpha/gamma agonist showed significant increases in treadmill endurance performance and reductions in fat mass, with histological evidence of increased skeletal muscle mitochondrial density and oxidative fibre proportion.

Cell Metabolism, 2023
3

Estrogen-related receptors as therapeutic targets for metabolic disease

ERR-alpha and ERR-gamma govern the transcriptional response to exercise in skeletal muscle and heart, making them high-value pharmacological targets for metabolic disease, sarcopenia, and heart failure — contexts where increasing mitochondrial function and fat oxidation is therapeutically beneficial.

Nature Reviews Drug Discovery, 2021
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
5★
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4★
67%
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N
Nathan K.
Vancouver, BC · Endurance / Fat Loss
★★★★★
✓ Verified Purchase
The newest frontier in metabolic peptides

The ERR mechanism is distinct from everything else I have used. After 6 weeks I can feel the difference in fat oxidation efficiency — both in fasted cardio performance and body composition trend. Stacking with AICAR.

O
Owen S.
Toronto, ON · Body Composition
★★★★☆
✓ Verified Purchase
Very early to judge but trend is positive

Only 4 weeks in. Endurance metrics are improving and body composition is trending favourably. The science on the ERR pathway is compelling. More data needed but initial n=1 result is encouraging.

B
Brendan W.
Ottawa, ON · Research
★★★★☆
✓ Verified Purchase
Interesting compound for serious researchers

The 2023 Nature Chemical Biology paper is what convinced me to try this. Novel mechanism, preliminary but solid preclinical data. Treating it as frontier research — tracking biomarkers carefully.

Common Questions

Frequently Asked Questions

AICAR and MOTS-c activate AMPK — a kinase that senses cellular energy status and triggers upstream metabolic switches. SLU-PP-322 activates ERR-alpha and ERR-gamma, nuclear transcription factors that directly regulate the genes encoding mitochondrial and fat oxidation enzymes. These are complementary parts of the same exercise adaptation cascade: AMPK upstream, ERRs downstream. Combining them may address both regulatory levels simultaneously.
SLU-PP-322 is an early-stage research compound. The primary data is from the 2023 Nature Chemical Biology publication and associated rodent studies. There is currently no published human clinical trial. Human dose estimates are extrapolated from allometric scaling of preclinical effective doses. This is frontier research territory.
Preclinical effective doses in mice were in the range of 2-10 mg/kg. Allometric scaling to humans (using the standard 12x body weight conversion factor) suggests 50-200 mg as a human-equivalent range. Given the early state of human data, starting at the lower end with conservative dose escalation is the appropriate approach.
Both compounds target the transcriptional level of metabolic gene expression — GW501516 activates PPARdelta while SLU-PP-322 activates ERRs. These are distinct nuclear receptor families with partially overlapping gene targets (fat oxidation, mitochondrial biogenesis) and partially distinct targets. The combination has not been directly studied but the mechanistic complementarity is plausible.
Despite the name, ERRs (Estrogen-Related Receptors) do not bind oestrogen and are not involved in reproductive biology. They are named for their structural similarity to classical oestrogen receptors discovered earlier. ERRs regulate metabolic gene programs and are not expected to produce hormonal side effects.
Yes — ERRs are metabolic receptors not reproductive hormonal receptors. There are no known oestrogen-related side effects from ERR agonism. Both men and women have the same metabolic ERR-dependent gene programs in skeletal muscle and the same theoretical benefit from their activation.
SLU-PP-322 SLU-PP-322
$92.00