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Senolytic · SubQ 99%+ Purity FOXO4-DRI
Longevity

FOXO4-DRI

FOXO4-DRI — first-in-class senolytic peptide that selectively eliminates senescent cells by disrupting the FOXO4-p53 survival complex that keeps them alive.

★★★★☆ 4.3 · 28 verified reviews · See all
$340.00
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Key Benefits
  • Selectively triggers apoptosis in senescent cells — does not harm healthy cells
  • Demonstrated tissue rejuvenation and improved physical function in aged mice
  • Addresses the root cause of inflammaging — accumulation of zombie cells
  • Fur regrowth, kidney function, and exercise tolerance improvements in preclinical models
  • Complements senolytics like quercetin/dasatinib with a peptide-based mechanism
Protocol Builder

Dosage Calculator

Reference dosing by experience level. For research use only — always consult a licensed healthcare provider.

Suggested Dose
—
Select experience level and click Show Protocol
Reconstitution Guide
—
Based on 5mg vial + 2mL BAC water
Suggested Cycle Length
8–12 weeks
For research reference only

⚠ For research reference only. FOXO4-DRI is not approved for human use. Always consult a qualified healthcare professional.

In Every Order

What's in the Box

Every Poptides order arrives in premium packaging, ready to use.

💊

FOXO4-DRI Vial

Your selected amount of lyophilized FOXO4-DRI in a sealed, sterile glass vial with silver crimp cap. COA included on request.

💧

BAC Water 3mL

Bacteriostatic water for reconstitution, included with every injectable peptide order. Maintains sterility for multi-dose use.

💉

Syringe Kit

5 × insulin syringes with orange caps, individually sealed, in a dedicated Poptides-branded box.

📋

Research Guide Card + Thank You Note

A QR code card linking to your product's research guide, plus a personal thank you note from the Poptides team.

📦

Discreet Outer Packaging

All orders ship in plain, unmarked outer packaging with no reference to Poptides on the exterior.

Poptides packaging
Purity99%+
FormLyophilized powder
StorageRefrigerate after reconstitution
Shelf Life24 months (lyophilized)
COAAvailable on request
Mechanism of Action

How FOXO4-DRI Works

The mechanism of action, step by step.

01

FOXO4-p53 Complex Disruption

Senescent cells survive by sequestering p53 in the cytoplasm via interaction with FOXO4, preventing p53 from entering the nucleus and triggering apoptosis. FOXO4-DRI competes with endogenous FOXO4 for p53 binding, freeing p53 to initiate programmed cell death.

02

Selective Senescent Cell Elimination

Because only senescent cells rely on the FOXO4-p53 survival complex, FOXO4-DRI's mechanism is cell-type selective — healthy, proliferating cells express different survival signals and are unaffected by the peptide.

03

SASP Reduction

Senescent cells secrete a Senescence-Associated Secretory Phenotype (SASP) of inflammatory cytokines, proteases, and growth factors that damage surrounding tissue. Eliminating these cells reduces the chronic SASP-driven inflammation underlying age-related tissue deterioration.

04

Tissue Rejuvenation

Following senescent cell clearance, resident stem cell populations are released from SASP-mediated inhibition, enabling tissue repair and regeneration that was suppressed by the senescent cell burden.

Dosing Protocols

Research Protocol

Published preclinical dosing guidelines for reference.

Typical Dose
1-5 mg
Per injection session
Session Protocol
3 days on / rest
Pulse dosing approach from mouse studies
Frequency
Every 6-12 months
Intermittent senolytic cycles
Senolytic Pulse
3 consecutive days
Based on original van Deursen protocol
Interval
6-12 months
Between pulse cycles
Monitoring
p16/p21 SASP markers
Longevity biomarker panel pre/post
Peer-Reviewed Research

The Science Behind It

Peer-reviewed research supporting the mechanism of FOXO4-DRI.

1

Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging

FOXO4-DRI selectively induced apoptosis in senescent cells in vitro and in vivo, reducing senescent cell burden in naturally aged mice. Treated mice showed improvement in fur density, kidney function, and physical fitness compared to controls.

Cell, 2017
2

Clearance of senescent cells reverses age-related phenotypes

Genetic and pharmacological senescent cell clearance in transgenic and aged mouse models reversed multiple hallmarks of aging including loss of physical function, impaired wound healing, and cardiovascular deterioration.

Nature, 2016
3

SASP cytokines and the systemic consequences of senescent cell accumulation

The Senescence-Associated Secretory Phenotype drives chronic sterile inflammation, impairs stem cell function, and promotes cancer growth — highlighting the systemic rationale for targeted senolytic intervention.

Nature Reviews Molecular Cell Biology, 2019
Verified Purchases

Customer Reviews

Verified purchases from Canadian customers.

4.3
★★★★☆
Based on 3 reviews
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4★
67%
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Edward C.
Vancouver, BC · Longevity
★★★★★
✓ Verified Purchase
The most mechanistically interesting compound I've used

The science behind this one is unlike anything else. Three-day pulse 6 months apart. Hard to quantify subjectively but my longevity markers trend significantly better since adding this to my protocol.

I
Irene B.
Toronto, ON · Cellular Anti-Aging
★★★★☆
✓ Verified Purchase
Fascinating and genuinely novel

Very few compounds have a paper in Cell as their primary reference. The selectivity of the mechanism is what sold me. Early days but energy and recovery seem improved post-pulse.

P
Paul H.
Calgary, AB · Anti-Aging Research
★★★★☆
✓ Verified Purchase
Sobering compound to research

Spent weeks reading the van Deursen papers before starting. This is not casual — it is real senolytic biology. Start at low dose and give your body time between cycles to adapt.

Common Questions

Frequently Asked Questions

Quercetin and dasatinib are small-molecule senolytics that act on broad anti-apoptotic survival pathways. FOXO4-DRI targets a single protein-protein interaction — FOXO4 binding to p53 — that is specifically upregulated in senescent cells. This gives it exceptional selectivity: only cells relying on this exact survival mechanism are targeted.
The preclinical protocol uses 3 consecutive daily injections, repeated at 6-12 month intervals. The rationale is that senescent cells accumulate slowly — excessive clearance frequency is unnecessary and the biology suggests less-frequent, higher-impact pulses are more appropriate than continuous dosing.
Some users report mild fatigue, transient inflammation, or flu-like sensations during the 3-day pulse — potentially reflecting inflammatory signalling from eliminated senescent cells. These typically resolve within 1-2 weeks. Many report improved energy and clarity 2-3 weeks after the cycle completes.
The foundational evidence is preclinical (mouse models). The 2017 Cell paper is compelling but human RCT data is not yet available. Clinically, the compound is used by longevity physicians in monitored protocols. Users should treat it as frontier longevity research rather than established clinical therapy.
Yes. A common longevity protocol stacks FOXO4-DRI with quercetin/fisetin (small-molecule senolytics acting through different pathways) for complementary senescent cell clearance. They can be run in the same cycle or alternated.
The 2017 Cell paper showed selective elimination of senescent cells with no significant effect on healthy, proliferating cells or post-mitotic cells. The mechanism is inherently selective because only senescent cells rely on the FOXO4-p53 cytoplasmic sequestration for survival.
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$340.00