HGH (Human Growth Hormone)

HGH is the actual somatotropin molecule — exogenous replacement of what the pituitary produces. GH secretagogues (sermorelin, ipamorelin, CJC-1295) stimulate the pituitary to produce its own GH. Secretagogues preserve pituitary function and produce more physiological GH pulses; direct HGH allows more precise dosing and higher IGF-1 elevation.

For general wellness and anti-aging, 1-2 IU daily (often at bedtime) is typical. For body composition goals, 2-4 IU split between morning and post-workout is more common. Higher doses carry greater risk of side effects.

Carpal tunnel syndrome, water retention, and elevated fasting glucose are the most common at higher doses. These are dose-dependent and generally resolve on dose reduction. IGF-1 and fasting glucose monitoring every 6-8 weeks is advisable.

Bedtime injection leverages the natural nocturnal GH pulse and maximises recovery effects. Morning fasted injection is preferred for fat-loss priorities. Avoid injecting with high-carbohydrate meals as insulin blunts GH activity.

Sleep quality improvements often appear within 2-4 weeks. Body composition changes are gradual — meaningful fat loss and lean mass changes typically become apparent at 8-12 weeks, with continued improvement over 3-6 months.

Yes — exogenous HGH suppresses pituitary GH release via negative feedback. This is reversible on discontinuation. This is one reason some researchers prefer secretagogues (sermorelin, ipamorelin) which stimulate rather than replace endogenous production.